Warfarin Genotype Polymorphisms in Kazakhstani Patients with Mechanical Circulatory Support - Left Ventricular Assist Devices

Left ventricular assist devices (LVADs) have dramatically increased the survival of adults with end-stage systolic heart failure. However, rates of bleeding and thromboembolism remain high. Warfarin is a commonly used anticoagulant with a narrow therapeutic index and high rate of significant adverse reactions from both over- and under-dosing. Several studies have shown that pharmacogenomic variants help predict stable warfarin dosing. Polymorphisms for VKORC1 and CYP2C9 are associated with increased warfarin sensitivity.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Source Type: research