Antihypertensive potential of linalool and linalool complexed with β-cyclodextrin: effects of subchronic treatment on blood pressure and vascular reactivity.

Antihypertensive potential of linalool and linalool complexed with β-cyclodextrin: effects of subchronic treatment on blood pressure and vascular reactivity. Biochem Pharmacol. 2018 Feb 15;: Authors: Camargo SB, Simões LO, de Azevedo Medeiros CF, de Melo Jesus A, Fregoneze JB, Evangelista A, Villarreal CF, de Souza Araújo AA, Quintans-Júnior LJ, Silva DF Abstract Linalool (LIN) is a monoterpene alcohol present in some aromatic medicinal plants with biological activities that can impact cardiovascular diseases. This chemical class is highly volatile and β-cyclodextrin (β-CD) has been employed to improve the pharmacological properties of monoterpenes. Thus, the aim of this study was to evaluate the cardiovascular effects of LIN free focusing on the antihypertensive properties of this monoterpene and to study whether LIN, complexed in β-cyclodextrin (LIN-βCD) is able to improve the pharmacological activity of LIN. Spontaneously hypertensive rats (SHR) were randomly divided into 5 groups, each treated daily for 21 days, in the following manner: group 1 (vehicle solution); group 2 (captopril; 30 mg/kg/day); group 3 (LIN; 100 mg/kg/day); group 4 (LIN; 50 mg/kg/day) and group 5 (LIN/β-CD; 50 mg/kg/day). Daily body weight measurements were conducted and mean arterial pressure and heart rate were measured every 5 days. The mesenteric artery from treated animals was tested for phenylephrine and sodium nitroprusside (SNP) sensitivity. ...
Source: Biochemical Pharmacology - Category: Drugs & Pharmacology Authors: Tags: Biochem Pharmacol Source Type: research