The Lower the LDL the Better but How and How Much?

In this issue of Trends in Cardiovascular Medicine, in a comprehensive review, Packard concludes that the lower the level of low-density lipoprotein cholesterol (LDL), the better [1]. This finding should be viewed in the context of the totality of evidence. In descriptive studies, useful to formulate, but not test, hypotheses, before the introduction of western lifestyles, the majority of the adult population of the world had LDLs of about 50 mg per deciliter (mg/dL). Japan has had the longest life expectancy in the world as well as the history of the world, due mainly to very low rates of coronary heart disease (CHD).

Source: Trends in Cardiovascular Medicine - February 2, 2018 Category: Cardiology Authors: Alexander Gitin, Marc A. Pfeffer, Charles H. Hennekens Source Type: research