Clonal Alterations and Survival after Unrelated Donor Allogeneic Hematopoietic Stem Cell Transplant in Patients with Fanconi Anemia

Background: Studies of bone marrow cell clonal alterations in patients with Fanconi anemia (FA), a cancer-prone inherited bone marrow failure (BMF) syndrome, have focused on their role in progression from BMF to myelodysplastic syndrome (MDS) or acute myeloid leukemia (AML). The role of such alterations on patient outcomes after hematopoietic cell transplantation (HCT) is unknown.

Source: Biology of Blood and Marrow Transplantation - February 1, 2018 Category: Hematology Authors: Youjin Wang, Weiyin Zhou, Tao Wang, Stephen R. Spellman, Michael Haagenson, Meredith Yeager, Blanche P. Alter, Stephanie J. Lee, Sharon A. Savage, Shahinaz M. Gadalla Source Type: research