Antidepressant-Like Effect of Lipid Extract of Channa striatus in Postpartum Model of Depression in Rats.

This study evaluated the antidepressant-like effect of lipid extract of C. striatus fillet and its mechanism of action in female Sprague-Dawley rats in postpartum model of depression. The rats were ovariectomized and treated with high dose of progesterone and estradiol benzoate for 23 days to have hormone-simulated pregnancy. The day 24 and afterwards were considered as the postpartum period. During the postpartum period, lipid extract was administered at 125, 250, and 500 mg/kg through intraperitoneal route for 15 days. Fluoxetine (10 mg/kg) was used as the positive control. On postpartum day 15, the animals were tested in forced swimming test (FST) and open field test (OFT) followed by biochemical analysis. Withdrawal of hormone administration during the postpartum period induced depressive-like behavior in FST. Administration of lipid extract reversed that depressive-like behavior at 125, 250, and 500 mg/kg in FST. In OFT, it decreased the exploratory activity. The mechanism of the antidepressant-like effect may be mediated through the decrease in plasma corticosterone, increase in plasma oxytocin, and decrease in nuclear factor-kappa B in prefrontal cortex of rats. PMID: 29317891 [PubMed]
Source: Evidence-based Complementary and Alternative Medicine - Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

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Conclusion: In addition to considering other risk factors for postpartum depression, health care providers should consider the higher probability of PPD in prepregnancy normal and overweight women who have excessive weight gain especially in the third trimester of pregnancy. PMID: 30420921 [PubMed - in process]
Source: Journal of Pregnancy - Category: OBGYN Tags: J Pregnancy Source Type: research
Publication date: Available online 12 November 2018Source: European Journal of Obstetrics &Gynecology and Reproductive BiologyAuthor(s): Brendan P. McDonnell, Sheila Keogan, Luke Clancy, Carmen ReganAbstractObjectiveMaternal cigarette smoking is a recognised risk factor for maternal and fetal morbidity and mortality and remains a significant problem in the Irish maternity system. Approximately 11% of Irish women will continue to smoke in pregnancy, despite awareness of the negative impact on their pregnancy. Although recommendations exist for the management of pregnant smokers, information on the antenatal care of Iris...
Source: European Journal of Obstetrics and Gynecology and Reproductive Biology - Category: OBGYN Source Type: research
AbstractPurposeThe aim was to determine the prevalence and risk factors of postpartum depression, and changes over time from pregnancy to postpartum period.Design and MethodsA prospective cohort study was conducted in 23 cities in Turkey, with 497 pregnant women.FindingsOf women, 13.5% had a high level of depressive symptoms during pregnancy and 4.8% during the postpartum period. Significant relationships emerged between total Edinburgh Postnatal Depression Scale score and mean age of participants and their husbands, duration of marriage, parity, and history of receiving professional psychological support.Practice Implicat...
Source: Perspectives In Psychiatric Care - Category: Psychiatry Authors: Tags: ORIGINAL ARTICLE Source Type: research
The first 12 months after childbirth may represent a high-risk time for depression. In Ethiopia there is a paucity of evidence about its magnitude and associated factors during that period. So, the aim of this...
Source: BMC Pregnancy and Childbirth - Category: OBGYN Authors: Tags: Research article Source Type: research
ConclusionThis program was evaluated positively. The AALS, PTGI ‐J, EPDS, and STAI showed significant change after the program and the AALS, PTGI‐J, and STAI‐J showed significant correlations with the CNSS.
Source: Japan Journal of Nursing Science - Category: Nursing Authors: Tags: ORIGINAL ARTICLE Source Type: research
ConclusionAmong women receiving opioid agonist treatment, prenatal food insecurity appears to be associated with increased risk for neonatal abstinence syndrome pharmacological treatment.
Source: Addiction - Category: Addiction Authors: Tags: Short Report Source Type: research
This study aimed at identifying the extent and determinants of undernutrition among young pregnant women in Ethiopia. A multivariable regression analysis was fitted to identify determinants of undernutrition and anemia in a sample of 1,393 pregnant women. Risk ratios with 95% confidence interval were estimated. All the analyses were performed using STATA version 14 and adjusted for clustering. The study revealed that 38% of the women were undernourished and 22% were anemic. Improved maternal education (RR=0.94, 95% CI: 0.89, 0.98), higher wealth status (RR=0.72, 95% CI: 0.47, 0.95), higher minimum dietary diversity for wom...
Source: Maternal and Child Nutrition - Category: Nutrition Authors: Tags: ORIGINAL ARTICLE Source Type: research
Conclusion: This study concludes that as social support levels increase there is a decrease at postpartum depression risk. It is recommended that planning of interventions should be in accordance with the factors affecting the social support and depression levels at women in the postpartum period.
Source: Nigerian Journal of Clinical Practice - Category: Rural Health Authors: Source Type: research
Authors: Nayak AS, Nachane HB Abstract Out of the various risk factors for postpartum depression, use of pharmacotherapy during pregnancy is the most poorly understood. The present study aimed to establish risk of postpartum depression and suicidal ideations with antenatal use of alpha methyldopa. Out of the 100 postpartum women assessed, 77.78% of the women who were prescribed alpha methyldopa had significant postpartum depression. There was statistically significant risk of postpartum depression associated with alpha methyldopa (p = 0.026, OR = 6.45). There was no increased suicidal ri...
Source: Asian Journal of Psychiatry - Category: Psychiatry Tags: Asian J Psychiatr Source Type: research
Publication date: Available online 8 November 2018Source: Nutrition, Metabolism and Cardiovascular DiseasesAuthor(s): N. Di Biase, S. Balducci, C. Lencioni, A. Bertolotto, A. Tumminia, A.R. Dodesini, B. Pintaudi, T. Marcone, E. Vitacolonna, A. NapoliAbstractThe aim of this review is to provide general suggestions about physical activity (PA) in pre-gestational and gestational diabetes (GDM) and encourage women to take part in safe and effective activities throughout pregnancy, in the absence of other contraindications. Physical activity before, during pregnancy and postpartum has many positive effects on the mother as it c...
Source: Nutrition, Metabolism and Cardiovascular Diseases - Category: Nutrition Source Type: research
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