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Antidepressant-Like Effect of Lipid Extract of Channa striatus in Postpartum Model of Depression in Rats.

This study evaluated the antidepressant-like effect of lipid extract of C. striatus fillet and its mechanism of action in female Sprague-Dawley rats in postpartum model of depression. The rats were ovariectomized and treated with high dose of progesterone and estradiol benzoate for 23 days to have hormone-simulated pregnancy. The day 24 and afterwards were considered as the postpartum period. During the postpartum period, lipid extract was administered at 125, 250, and 500 mg/kg through intraperitoneal route for 15 days. Fluoxetine (10 mg/kg) was used as the positive control. On postpartum day 15, the animals were tested in forced swimming test (FST) and open field test (OFT) followed by biochemical analysis. Withdrawal of hormone administration during the postpartum period induced depressive-like behavior in FST. Administration of lipid extract reversed that depressive-like behavior at 125, 250, and 500 mg/kg in FST. In OFT, it decreased the exploratory activity. The mechanism of the antidepressant-like effect may be mediated through the decrease in plasma corticosterone, increase in plasma oxytocin, and decrease in nuclear factor-kappa B in prefrontal cortex of rats. PMID: 29317891 [PubMed]
Source: Evidence-based Complementary and Alternative Medicine - Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

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(Worcester Polytechnic Institute) Lifeline4Moms, an app developed by a researcher at Worcester Polytechnic Institute, gives obstetric providers an important new tool for assessing perinatal depression in women and guiding them to treatment. Perinatal depression affects one in seven women and is the most common medical complication of pregnancy. The app is a how-to decision aid, not a diagnostic tool, for obstetricians and other maternal healthcare providers, who generally are not trained to diagnose and treat psychiatric illness.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news
Depression in the postpartum period has been identified as the most common complication of childbearing years (Poyatos-Leon et al., 2017), with an estimated prevalence of 10-20 % in Western countries (Dennis and Hodnett, 2007, Falah-Hassani et al., 2015). Some women have continuation of depression that presented in pregnancy. For others it is of new onset. Women who experience perinatal complications or have a co-existing chronic disease have an even higher risk for postpartum depression (Turner et al., 2006)
Source: Journal of Affective Disorders - Category: Neurology Authors: Tags: Research paper Source Type: research
Children whose mothers experienced depression during and after pregnancy may be slower to hit early childhood developmental milestones than children whose mothers did not experience depression, suggests astudy published this week inDepression&Anxiety. The findings demonstrate the benefit that early recognition and treatment of maternal depression symptoms can have on both mothers and children.While previous studies have suggested symptoms of depression during and after pregnancy are associated with poorer neurodevelopmental outcomes in offspring, questions remain about whether such symptoms during pregnancy and postpar...
Source: Psychiatr News - Category: Psychiatry Tags: Ages and Stages Questionnaire ASQ Beck Depression Inventory Center for Epidemiological Studies Depression Scale childhood & Anxiety maternal depression pregnancy Soile Tuovinen Source Type: research
Within 24 hours of her second daughter’s birth, Dyane Harwood felt elated. From the moment she came home from the hospital, she started writing. Furiously. She wrote while nursing her daughter and going to the bathroom. She wrote on her hands, on the bathroom mirror, inside books and on tabletops. She yearned to write down every thought she was having. She wrote so much that her wrists ached—her carpal tunnel returning—and she was in constant pain. She also had endless energy and a newfound enthusiasm for life. She felt like she could run a long race. She couldn’t sit still, and her speech was fast ...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: Bipolar Disorders General Health-related Mental Health and Wellness Self-Help Sleep Women's Issues Johns mood disorder Motherhood Parenting postpartum bipolar disorder postpartum depression Postpartum Disorder Source Type: blogs
CONCLUSIONS: Maternal anxiety, depression and sleep disorders are associated with a relative increase in the number of ADHD-H, ADHD-I and total ADHD symptoms in preschoolers. PMID: 29665879 [PubMed - as supplied by publisher]
Source: Epidemiology and Psychiatric Sciences - Category: Psychiatry Tags: Epidemiol Psychiatr Sci Source Type: research
(Wiley) Maternal depressive symptoms during pregnancy, in the first year postpartum, and in early childhood were linked with poorer child neurodevelopment in a recent Depression&Anxiety study.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news
This study was a secondary data analysis of prospective data collected from a cohort of pregnant women (N  = 101) in an obstetric clinic of a large medical center. Maternal vitamin D deficiency (serum 25(OH)D ≤ 20 ng/ml) and depressive symptoms (Edinburgh Postnatal Depression Scale, EPDS) were assessed in early pregnancy. A composite of four adverse perinatal outcomes (low birth weight, prete rm birth, small-for-gestational age, and preeclampsia) were abstracted from medical charts. Nineteen of the 101 women had one or more adverse perinatal outcome and 84% with an adverse outcome (16/19...
Source: Journal of Behavioral Medicine - Category: Psychiatry Source Type: research
Conclusions are limited by the small number of studies, small sample sizes and incomplete outcome data due to study drop-out which may have led to bias in the results. We have assessed the certainty of the evidence as very low, based on the GRADE system. No data were available on secondary outcomes of interest including child development, the mother‒infant relationship, breastfeeding, maternal daily functioning, family relationships or maternal satisfaction. AUTHORS' CONCLUSIONS: Due to the limitations of the current evidence base, such as the low statistical power of the included studies, it is not possible to draw...
Source: Cochrane Database of Systematic Reviews - Category: General Medicine Authors: Tags: Cochrane Database Syst Rev Source Type: research
Depression and Anxiety, EarlyView.
Source: Depression and Anxiety - Category: Psychiatry Authors: Source Type: research
Conclusions This study aids to draw attention on the incorporation of routine screening for basic support and intervention for identified risk factors in postpartum period. Policies can be formulated to encourage postpartum women to obtain adequate rest during pregnancy, support women with poor partner relationship, reduce marital dissatisfaction, help women adjust with stressful life events, and prevent and manage abortion appropriately. These policies may reduce harmful consequences of postpartum depressive symptoms for women, newborn and their family.
Source: International Journal of Nursing Sciences - Category: Nursing Source Type: research
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