AJP Articles Make NEJM Journal Watch Psychiatry, BBRF ’s Top 10 for 2017

This study found that once-daily treatment with valbenazine at 80 mg/day significantly improved the symptoms of tardive dyskinesia compared with placebo in a population of patients with schizophrenia, schizoaffective disorder, or a mood disorder. The med ication was generally well tolerated, even among patients taking concomitant antipsychotics, and the psychiatric status of the patients remained stable throughout the trial.In addition to the article by Sit and colleagues referenced above, the following studies were selected by BBRF in its list of the top advancements and breakthroughs by Foundation grantees in 2017 (in chronological order):“Multimodal Neuroimaging of Frontolimbic Structure and Function Associated With Suicide Attempts in Adolescents and Young Adults With Bipolar Disorder, ” by Jennifer A.Y. Johnston, M.A., et al. Relying on multiple MRI techniques, the authors of this study compared brain images of 68 participants aged 14 to 25 with bipolar disorder who did or did not have a prior suicide attempt. Their analysis revealed significant differences in brain structure and connectivity between these two groups. Intriguingly, among suicide attempters, reduced connections to the left or right prefrontal cortex were correlated with more serious suicidal ideation or suicide attempts, respectively.“Effect of a Novel NMDA Receptor Modulator, Rapastinel (Formerly GLYX-13), in OCD: Proof of Concept, ” by Carolyn I. Rodriguez, M.D., Ph.D., et al. In this ...
Source: Psychiatr News - Category: Psychiatry Tags: American Journal of Psychiatry bipolar depression bipolar disorder Brain and Behavior Research Foundation ketamine NEJM Journal Watch Psychiatry rapastinel tardive dyskinesia Source Type: research