Novel Mitochondria-Targeting Peptide in Heart Failure Treatment: A Randomized, Placebo-Controlled Trial of Elamipretide [Original Articles]
Conclusions
This is the first study to evaluate elamipretide in heart failure with reduced ejection fraction and demonstrates that a single infusion of elamipretide is safe and well tolerated. High-dose elamipretide resulted in favorable changes in left ventricular volumes that correlated with peak plasma concentrations, supporting a temporal association and dose–effect relationship. Further study of elamipretide is needed to determine long-term safety and efficacy.
Clinical Trial Registration
URL: https://www.clinicaltrials.gov. Unique identifier: NCT02388464.
Source: Circulation: Heart Failure - Category: Cardiology Authors: Daubert, M. A., Yow, E., Dunn, G., Marchev, S., Barnhart, H., Douglas, P. S., OConnor, C., Goldstein, S., Udelson, J. E., Sabbah, H. N. Tags: Metabolism, Cardiomyopathy, Heart Failure Original Articles Source Type: research
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