Human haematological and epithelial tumor-derived cell lines express distinct patterns of onco-microRNAs.

In this study, we analysed differences in miRNA expression profile between haematological and epithelial tumor-derived cell lines and explored their role in definying different cancer cells phenotypes. Cancer Focus microRNA PCR Panel was used to analyze eighty-four oncomiRNAs in two human haematological (K562 and HL-60) and in two epithelial (H460 and MCF-7) cancer cell lines. Bioinformatic tools were used to identify miRNA-specific signatures and to discover potentially deregulated pathways. Our analysis led to the identification of i) a large repertoire of miRNAs commonly expressed in the four cell lines, including two equally highly expressed (UPmiRs) and four equally low expressed (DNmiRs); ii) two miRNAs signatures, one associated with the haematological and one with the epithelial cell lines; iii) miRNA signatures specific for the acute or for the chronic myeloid leukemic cells; iv) miRNA signatures specific for the lung or for the breast carcinoma cells. As a whole, these results strengthen the significance of miRNAs profiling in human cancer subtyping, providing the ground for the identification of novel potential biomarkers for specific cancer cell phenotypes. PMID: 29208177 [PubMed - in process]
Source: Cellular and Molecular Biology - Category: Molecular Biology Tags: Cell Mol Biol (Noisy-le-grand) Source Type: research

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In this study, a simple but sensitive electrochemiluminescence (ECL) biosensor has been designed for HAase detection based on the electrostatic interaction of anionic hyaluronic acid (HA) and cationic luminous reagent Ru(bpy)32+. Ru(bpy)32+ is adsorbed on HA through electrostatic interaction to form HA-Ru(bpy)32+ complex. The Ru(bpy)32+ in the HA-Ru(bpy)32+ complex cannot be filtered out because of its large molecular weight. In the presence of HAase, the HA in HA-Ru(bpy)32+ can be cleaved into fragments by enzymatic hydrolysis. As a result, the Ru(bpy)32+ attached on the HA fragments can be separated from the HA-Ru(bpy)32...
Source: Sensors and Actuators B: Chemical - Category: Chemistry Source Type: research
Publication date: 1 November 2018Source: Inorganica Chimica Acta, Volume 483Author(s): Yeşim Salman, Fırat Barış Barlas, Murat Yavuz, Kerem Kaya, Suna Timur, Fatma Çetin TelliAbstractFour novel dinuclear Cu(II) complexes (1a–4a) have been prepared from ONO-tridentate chiral Schiff base derivatives of chloralose (1–4). All the new complexes (1a–4a) have been characterized by Fourier transform infrared spectroscopy, UV–visible spectroscopy and elemental analysis. The complex 2a was further characterized by X-Ray crystallography. And also, the magnetic susceptibility measurement of this comp...
Source: Inorganica Chimica Acta - Category: Chemistry Source Type: research
Reese Witherspoon and Keith Urban are among the stars joining the sixth Stand Up To Cancer telethon on Sept. 7.
Source: ABC News: Health - Category: Consumer Health News Tags: Health Source Type: news
BOWEL cancer risk could be reduced by making some diet or exercise changes. Eating more of this cheap vegetable could prevent the deadly disease, scientists have claimed. Its preventative effects are “striking”, they said.
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
Muhammad Junaid, from a small village in Mirpur Khas, Pakistan, suffers from Retinoblastoma - a type of carcinoma that usually affects children under the age of five.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
Freya Clarke, 26, from East Grinstead, Sussex, quit her sales and marketing job after becoming 'bored' with London life. Within days of arriving in Sydney, she was diagnosed.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
To outwit cancer, researchers are working on better ways to teach patients' immune system to root out and kill malignant cells. A promising approach involves cells that attack cancer two ways at once.(Image credit: Pearl Mak/NPR)
Source: NPR Health and Science - Category: Consumer Health News Authors: Source Type: news
In this study, we sought to further describe clinicopathologic findings in a large series of ACD-RCC, emphasizing histologic features, immunophenotype, clinical outcome, and patterns of disease spread. We collected 40 previously unpublished cases of ACD-RCC with mean clinical follow-up of 27 months (median, 19 mo; range, 1 to 126 mo). Mean tumor size was 2.7 cm (median, 2.4 cm), and 32 tumors (80%) were confined to the kidney (pT stage less than pT3a). International Society of Urological Pathology grade was 3 in 37 cases (92.5%), grade 2 in 1 case (2.5%), and grade 4 in 2 cases (5%). Architectur...
Source: The American Journal of Surgical Pathology - Category: Pathology Tags: Original Articles Source Type: research
CONCLUSION Cognitive impairment can affect daily functioning, quality of life, and capacity to work in patients with cancer and those in remission. Consequently, cognitive assessment is now an important and necessary part of a comprehensive oncological care plan. Cancer-related cognitive impairment might be due to the direct effects of the cancer itself, nonspecific factors, or comorbid conditions that are independent of the disease and/or due to the adverse effects of the treatment or combination of treatments given for the disease. The prevalence and extent of cognitive impairment associated with cancer is recognized but...
Source: Innovations in Clinical Neuroscience - Category: Neuroscience Authors: Tags: Cognition Current Issue Neuro oncology Neurology Review cancer chemotherapy cognitive impairment neuropsychological assessment treatment Source Type: research
In January, 2018, Academic Press published my bookPrecision Medicine and the Reinvention of Human Disease. This book has an excellent " look inside " at itsGoogle book site, which includes the Table of Contents. In addition, I thought it might be helpful to see the topics listed in the Book's index. Note that page numbers followed by f indicate figures, t indicate tables, and ge indicate glossary terms.AAbandonware, 270, 310geAb initio, 34, 48ge, 108geABL (abelson leukemia) gene, 28, 58ge, 95 –97Absidia corymbifera, 218Acanthameoba, 213Acanthosis nigricans, 144geAchondroplasia, 74, 143ge, 354geAcne, 54ge, 1...
Source: Specified Life - Category: Information Technology Tags: index jules berman jules j berman precision medicine Source Type: blogs
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