Bone marrow transplantation reduces susceptibility to pulmonary hypertension in BMPR2 deficient mice

Conclusions: The BM plays an important role in the development of PAH. We have shown that the susceptibility to PAH in the BMPR2+/- mouse can be conferred on a wild type animal by BM transplantation and that the BMPR2+/- mouse can be protected from the development of PAH by bone marrow transplantation with WT BM. Further elucidation of the role of the BM is required, but may point to a potential future therapeutic strategy in PAH.

Source: European Respiratory Journal - December 6, 2017 Category: Respiratory Medicine Authors: Crosby, A., Toshner, M., Soon, E., Southwood, M., Dunmore, B., Groves, E., Moore, S., Wright, P., Nicholas, M. Tags: Pulmonary Circulation and Pulmonary Vascular Disease Source Type: research