Therapeutic Effect of a Novel Wnt Pathway Inhibitor on Cardiac Regeneration after Myocardial Infarction

In conclusion, porcupine inhibitor CGX1321 reduces MI injury by limiting fibrosis and promoting regeneration. It promotes cardiomyocyte proliferation by stimulating cell cycle regulating genes with a Hippo/YAP independent pathway.

Source: Clinical Science - November 21, 2017 Category: Biomedical Science Authors: Zeng, C., Yang, D., Fu, W., Li, L., Xia, X., Liao, Q., Yue, R., Chen, H., Chen, X., An, S., Wang, W. E. Tags: PublishAheadOfPrint Source Type: research