Novel Gene and Network Associations Found for Acute Lymphoblastic Leukemia Using Case-Control and Family-Based Studies in Multiethnic Populations

Conclusions: Gene and network analysis uncovered loci associated with ALL that are missed by GWA studies, such as MEIS1. Furthermore, ALL-associated loci do not appear to interact directly with each other to influence ALL risk, and instead appear to influence leukemogenesis through multiple, complex pathways.
Impact: We present a new pipeline for post hoc analysis of association studies that yields new insight into the etiology of ALL and can be applied in future studies to shed light on the genomic underpinnings of cancer. Cancer Epidemiol Biomarkers Prev; 26(10); 1531–9. ©2017 AACR.

Source: Cancer Epidemiology Biomarkers and Prevention - October 1, 2017 Category: Cancer & Oncology Authors: Nakka, P., Archer, N. P., Xu, H., Lupo, P. J., Raphael, B. J., Yang, J. J., Ramachandran, S. Tags: Research Articles Source Type: research