Roles of autophagy and metabolism in pancreatic cancer cell adaptation to environmental challenges

This study provides evidence that the maintenance of mitochondrial function, in particular, oxidative phosphorylation (OXPHOS), is a key mechanism that supports PaCa cell growth, both in normal conditions and under the environmental stresses. OXPHOS in PaCa cells critically depends on autophagy and AA supply. Furthermore, the oncogenic activation mutation in GTPase Kras upregulates OXPHOS through an autophagy-dependent mechanism.

Source: AJP: Gastrointestinal and Liver Physiology - November 2, 2017 Category: Gastroenterology Authors: Maertin, S., Elperin, J. M., Lotshaw, E., Sendler, M., Speakman, S. D., Takakura, K., Reicher, B. M., Mareninova, O. A., Grippo, P. J., Mayerle, J., Lerch, M. M., Gukovskaya, A. S. Tags: RESEARCH ARTICLE Source Type: research