Cerebral amyloid angiopathy-related cognitive impairment: The search for a specific neuropsychological pattern.
Cerebral amyloid angiopathy-related cognitive impairment: The search for a specific neuropsychological pattern. Rev Neurol (Paris). 2017 Oct 06;: Authors: Planton M, Raposo N, Albucher JF, Pariente J Abstract Cerebral amyloid angiopathy is diagnosed in stroke units after lobar intracerebral hemorrhage. CAA can also be diagnosed in memory clinics when patients are referred for cognitive impairment assessment, and may be a reason for admission to emergency or neurology departments because of rapidly progressive cognitive or neurological decline, or a transient focal neurological episode. CAA may even be observed in older community-dwelling individuals. Neuropsychological impairment in CAA has been described over the past 20 years. The symptoms most commonly reported are perceptual speed, episodic memory, semantic memory, attention and executive function, and global cognitive impairments. Psychiatric symptoms, such as personality changes, behavioral disturbances and depression, have been more recently described. CAA is also a risk factor for the development of dementia, and its relationship with Alzheimer's disease has been demonstrated in post-mortem studies. Yet, despite the increase in literature on CAA-related cognitive and psychiatric symptoms, the specific characteristics of symptoms in CAA are difficult to assess because of the substantial prevalence of comorbidities such as small vessel disease due to high blood pressure, Lewy body disease and, of co...
CONCLUSIONS: The studies lacked a systematic approach to investigating risk factors for depression, and the research remains largely atheoretical. Few risk factors were consistently studied, with over 20 risk factors examined no more than once each. Psychological and environmental risk factors, which may be modifiable and have the potential to inform therapeutic interventions and preventative strategies, remain under-studied. CLINICAL IMPLICATIONS: The most consistently supported risk factors - cognitive impairment, functional disability and baseline depression score - have the potential to inform screening protocols a...
Authors: Abstract Parkinson\'s disease (PD) is often accompanied by significant changes in emotionality, such as apathy, anhedonia, anxiety and depression. The present review summarizes the empirical evidence, including amygdala changes and psychological changes in emotionality in people suffering with PD. Seventeen empirical full-text articles including research on both amygdala and emotionality in PD were reviewed.The changes in amygdala volumes as well as changes in binding potentials, functional connectivity, regional homogeneity and regional cerebral blood flow were found to have various impacts on emotionali...
Researchers funded by the National Institutes of Health have shown that a therapy-based treatment for disruptive behavioral disorders can be adapted and used as an effective treatment option for early childhood depression.
(Reuters Health) - Even when the heart rhythm disorder known as atrial fibrillation goes away after treatment, patients' risk of stroke may still be higher than average, a large UK study suggests.
The study was a randomized, controlled trial.
There is a decades-long legacy of studies showing the adverse health affects that children suffer after separation from their parents - from toxic stress and depression to heart disease and cancer.
CONCLUSIONS: MiRNA-26a promotes angiogenesis in a rat model of cerebral ischemic via PI3K/AKT and MAPK/ERK pathway. PMID: 29917203 [PubMed - in process]
(MedPage Today) -- Randomized trial shows clear effect, but too few boys to tell whether they also benefitted
Researchers from the Nutrition Research Centre Ireland believe that a combination of nutrients found in trout, broccoli and peppers significantly improves the memories of patients after 18 months.
Conclusions: This pilot study suggests that FPP AOT is a feasible intervention and the research protocol designed would be suitable, with minor modifications, for the conduction of a subsequent stage 2 trial designed to verify the hypothesis that the adjunct of FPP AOT might improve motor performance in individuals with IPD.