Severe cerebellar hemorrhage following transverse sinus stenting for idiopathic intracranial hypertension.

We report a severe adverse event occurring in the course of a cohort study (ISRCTN13784335) aimed at measuring the efficacy and safety of venous stenting in the treatment of patients with medically refractory idiopathic intracranial hypertension (IIH). The patient was a 41-year-old woman who was not overweight, who presented with severe headache, grade 1 bilateral papilledema and transient tinnitus, refractory to medical treatment. Right transverse sinus stenting was successfully performed. Following surgery, the patient's state of consciousness decreased acutely with rapid and progressive loss of brainstem reflex. CT scan revealed acute cerebellar and intraventricular hemorrhage with obstructive hydrocephalus. Angioscan revealed normal venous sinus patency and cerebral MRI showed acute mesencephalic ischemia. Mechanical impairment of cerebellar venous drainage by the stent or venous perforation with the large guidewire used in this technique are two logical ways to explain the cerebellar hemorrhage seen in our patient. The risk of such a complication could probably be reduced using alternative tools and technique. However, given the low level of evidence around the safety of transverse sinus stenting in IIH, its formal assessment in clinical trials is required. PMID: 28992723 [PubMed - as supplied by publisher]
Source: Interventional Neuroradiology - Category: Radiology Tags: Interv Neuroradiol Source Type: research

Related Links:

Authors: Benchoula K, Khatib A, Jaffar A, Ahmed QU, Sulaiman WMAW, Wahab RA, El-Seedi HR Abstract Metabolic syndrome is a cluster including hyperglycaemia, obesity, hypertension, and hypertriglyceridaemia as a result of biochemical and physiological alterations and can increase the risk of cardiovascular disease and diabetes. Fundamental research on this disease requires validated animal models. One potential animal model that is rapidly gaining in popularity is zebrafish (Danio rerio). The use of zebrafish as an animal model conveys several advantages, including high human genetic homology, transparent embryos and...
Source: Experimental Animals - Category: Research Tags: Exp Anim Source Type: research
AbstractIn this research, the copper hexacyanoferrate/SBA-15 composite was prepared by embedding method, which was further characterized using scanning electron microscope, Fourier transform infrared spectroscopy, X-ray photoelectron spectroscopy, Brunauer –Emmett–Teller, transmission electron microscopy and X-ray diffraction. The effects of different factors such as pH, temperature, contact time, initial cesium concentration on adsorption were studied. The pH significantly influenced the adsorption. The pseudo second-order kinetic model fitted th e adsorption well, indicating chemisorption. The Langmuir isothe...
Source: Journal of Radioanalytical and Nuclear Chemistry - Category: Nuclear Medicine Source Type: research
Publication date: Available online 23 May 2019Source: Journal of Materials Research and TechnologyAuthor(s): An Huang, Honglian Dai, Xiaopei Wu, Zheng Zhao, Yanzeng WuAbstractThe mesoporous hydroxyapatite (HAP) powder was synthesized by using the microemulsion (hexadecyltrimethyl ammonium bromide (CTAB)/cyclohexane/n-octyl alcohol) system. The optimal ratios of concentrations of CTAB, cyclohexane and n-octyl alcohol in the microemulsion on morphology of the HAP were studied. The effects of pHs and calcination temperatures on the phase composition of the HAP powder were discussed. The phase composition, morphology, mesoporo...
Source: Journal of Materials Research and Technology - Category: Materials Science Source Type: research
Publication date: Available online 24 May 2019Source: Mechanics of MaterialsAuthor(s): S.M.R. Paran, R. Sahraeian, G. Naderi, A. RashidiAbstractThe effect of various concentrations of mulitwalled carbon nanotubes (MWCNTs) on the elastoplastic behavior, thermal and rheological properties of compatibilized nanocomposites based on low density polyethylene containing poly(methyl hydrogen siloxane)-grafted perlite was explored through using experimental and theoretical analysis. The nanocomposites were prepared by using melt mixing procedure and characterized by various experimental measurements including scanning electron micr...
Source: Mechanics of Materials - Category: Materials Science Source Type: research
Publication date: August 2019Source: Carbon, Volume 149Author(s): Benjamin W. Caplins, Jason D. Holm, Robert R. KellerAbstractA scanning transmission electron diffraction method is developed for use in the scanning electron microscope to perform orientational characterization of 2D materials. The method can generate orientation maps of monolayer graphene over a field of view up to ≈50μm in just a few minutes and can distinguish twisted bilayers from aligned bilayers. This method holds promise to bring electron-diffraction-based orientation measurements of 2D materials to a broader audience.Graphical abstract
Source: Carbon - Category: Materials Science Source Type: research
ConclusionCrisPam is an algorithm that scans DNA sequences of SNPs and detects PAMs generated by pathogenic SNPs. A SNP is accepted as a match if a PAM is found at the pathogenic allele and not at the wildtype allele.ResultsUsing CrisPam we found that 83% of the SNPs generate at least one PAM. 49,826 pathogenic SNPs and 14,755 likely pathogenic SNPs (64,581 in total) were scanned and analyzed. The obtained database contains the SNP information and the Cas proteins for whom a PAM was generated by a pathogenic SNP.ConclusionsWe have developed CrisPam, a web tool available to researchers for designing their own CRISPR-based e...
Source: Cytotherapy - Category: Cytology Source Type: research
ConclusionHere in this project, AAV vector with functional ABCD1 gene is constructed and its effectiveness is being tested in vitro for treating X-ALD. Meanwhile, a new animal model – ABCD1 gene mutated rabbit is used to mimic condition of X-ALD patients. Compared to the same age wild type rabbits, the diseased model shows a 5-10 folds increase in plasma VLCFA level before the treatment, and magnetic resonance imaging (MRI) scan is performed to determine demyelination inside the CNS.After AAV injection, rabbits' blood VLCFA level is monitored regularly, MRI scan and brain tissue sectioning are examined to determine t...
Source: Cytotherapy - Category: Cytology Source Type: research
Authors: Favoccia C, Constantine AH, Wort SJ, Dimopoulos K Abstract Introduction: Eisenmenger syndrome (ES) is the most advanced form of pulmonary arterial hypertension (PAH) in patients with congenital heart disease (CHD). It is characterised by a severe rise in pulmonary vascular resistance resulting in shunt reversal and cyanosis. Areas covered: In this paper, an overview of ES and other types of PAH related to CHD (PAH-CHD) in adults is provided. The modern management of PAH-CHD in tertiary centers, with emphasis on co-morbidities and complications is described. Expert opinion: PAH-CHD is a wide spectrum of con...
Source: Expert Review of Cardiovascular Therapy - Category: Cardiology Tags: Expert Rev Cardiovasc Ther Source Type: research
Conclusion: Our findings suggest that long-term RIC treatment has mild anti-inflammatory effects in patients with compensated CIHF and anti-remodeling effects in those with increased NT-proBNP levels. This should be further investigated in a randomized sham-controlled trial. PMID: 31117835 [PubMed - as supplied by publisher]
Source: Scandinavian Cardiovascular Journal - Category: Cardiology Tags: Scand Cardiovasc J Source Type: research
Publication date: Available online 23 May 2019Source: Neuroscience &Biobehavioral ReviewsAuthor(s): Lea Boecker, Paul PauliAbstractStartle reflex potentiation versus startle attenuation to unpleasant versus pleasant stimuli likely reflect priming of the defensive versus appetitive motivational systems, respectively. This review summarizes and systemizes the literature on affective startle modulation related to psychopathologies with the aim to reveal underlying mechanisms across psychopathologies. We found evidence for psychopathologies characterized by increased startle potentiation to unpleasant stimuli (anxiety diso...
Source: Neuroscience and Biobehavioral Reviews - Category: Neuroscience Source Type: research
More News: Brain | Clinical Trials | CT Scan | Headache | Hydrocephalus | Hypertension | Migraine | Neurology | Neurosurgery | Obesity | PET Scan | Radiology | Reflex Sympathetic Dystrophy | Study | Tinnitus