Podoplanin Expression and Its Preclinical Application for Near-Infrared Imaging for Oral Squamous Cell Carcinoma

Podoplanin, which is a 38  kDa type I transmembrane glycoprotein, was initially identified as a platelet aggregation-inducing factor in cancer cells, and plays an important role in the formation of lymphatic vascular systems. Podoplanin is also expressed in many types of cancers such as lung cancer, cervical cancer, skin ca ncer, and esophageal cancer. Previous studies have reported that approximately 60%-70% of oral squamous cell carcinoma (OSCC) showed overexpression of podoplanin, suggesting a role in tumor progression and metastasis thorough various mechanisms.
Source: Journal of Oral and Maxillofacial Surgery - Category: ENT & OMF Authors: Tags: Oral Abstract Track Four: Medicine, Pathology, Trauma Source Type: research