ER-associated degradation is required for vasopressin prohormone processing and systemic water homeostasis

This study highlights a pathway linking ERAD to prohormone conformational maturation in neuroendocrine cells, expanding the role of ERAD in providing a conducive ER environment for nascent proteins to reach proper conformation.

Source: Journal of Clinical Investigation - September 18, 2017 Category: Biomedical Science Authors: Guojun Shi, Diane Somlo, Geun Hyang Kim, Cristina Prescianotto-Baschong, Shengyi Sun, Nicole Beuret, Qiaoming Long, Jonas Rutishauser, Peter Arvan, Martin Spiess, Ling Qi Source Type: research