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An analysis of clinical characteristics and patient outcomes in primary mediastinal sarcomas.

This study reviewed the clinical features and outcomes of these cases from the SEER (surveillance, epidemiology and end results) database. METHODS: Primary mediastinal sarcomas, diagnosed from 1988 to 2013 were assembled from the SEER database. The incidence and 10-year cancer-specific survival rates were compared to other primary mediastinal malignancies (thymic carcinomas, germ cell tumors, neurogenic tumors, Hodgkin and non-Hodgkin lymphomas) as well as to non-mediastinal sarcomas. Cox-proportional hazard models were utilized to produce multivariate analyses for factors affecting overall survival among primary mediastinal sarcoma patients. RESULTS: A total of 204 patients were recruited into this cohort. Multivariate analysis showed better overall survival for patients with a younger age at diagnosis, low grade [hazard ratio 0.427 (95% CI: 0.224-0.814; P= 0.010)], posterior mediastinum location [hazard ratio 0.458 (95% CI: 0.268-0.781; P= 0.004)], node negative disease [hazard ratio 0.463 (95% CI: 0.232-0.923; P= 0.029)] and surgical treatment [hazard ratio 0.488 (95% CI: 0.336-0.709; P
Source: Expert Review of Anticancer Therapy - Category: Cancer & Oncology Tags: Expert Rev Anticancer Ther Source Type: research

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CONCLUSIONS: The incidence of cervical cancer in Jordan is low compared to regional estimates and remained relatively constant between 2008 and 2013. Implementation of screening measures could lead to better case finding, early diagnosis, and prevention of cervical cancer. PMID: 28932241 [PubMed]
Source: Journal of Oncology - Category: Cancer & Oncology Tags: J Oncol Source Type: research
ConclusionsIntegrated medical and psychiatric care is needed to improve outcomes of cancer care among patients with SMI. PMID: 28935659 [PubMed - as supplied by publisher]
Source: The British Journal of Psychiatry for Mental Science - Category: Psychiatry Tags: Br J Psychiatry Source Type: research
ZURICH (Reuters) - Roche immunotherapy Tecentriq has won European Union approval for treating advanced lung and bladder cancer, the Swiss drugmaker said.
Source: Reuters: Health - Category: Consumer Health News Tags: healthNews Source Type: news
Purple potatoes and other colorful fruits and vegetables could help to prevent colon cancer by reducing levels of a pro-inflammatory protein.
Source: Health News from Medical News Today - Category: Consumer Health News Tags: Nutrition / Diet Source Type: news
This study aimed to develop a method for eliciting and coding recall of medical information in non‐English‐speaking patients. DesignThis method, called Patient‐Interpreter‐Clinician coding (PICcode), was developed in the context of a phase II trial conducted in two outpatient oncology clinics in Melbourne, Australia, and was refined iteratively through consultation with an expert panel and piloting. Between‐coder differences in early versions of the coding system were resolved through discussion and consensus resulting in refinements to PICcode. ResultsThe final version of PICcode involved transcribing, translati...
Source: Health Expectations - Category: Health Management Authors: Tags: ORIGINAL RESEARCH PAPER Source Type: research
Contributor : Stephanie RoesslerSeries Type : Non-coding RNA profiling by arrayOrganism : Homo sapiensGallbladder carcinoma (GBC) is a rare cancer entity in Western Europe and the US with an incidence of less than 3/100.000 and a survival rate
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Non-coding RNA profiling by array Homo sapiens Source Type: research
In this study, we performed recursive partitioning analysis (RPA) to objectively combine the 15-ELN threshold and 8th AJCC stage to refine the staging for GC.MethodsWe analyzed 19,018 patients with non-metastatic GC from the Surveillance, Epidemiology, and End Results database. The dataset was randomly divided into training and validation sets.ResultsFor each 8th AJCC stage, survival was significantly better for patients with ≥15 ELNs versus those with
Source: Journal of Gastrointestinal Surgery - Category: Surgery Source Type: research
ConclusionNeoadjuvant therapy prior to gastric resection for gastric cancer is not associated with an increased risk of anastomotic leak or other additional short-term morbidity or mortality.
Source: Journal of Gastrointestinal Surgery - Category: Surgery Source Type: research
Conclusions: Application of metastatic prognostic scoring systems to a retrospective surgical cohort revealed an overall poor correlation with the Tomita and revised Tokuhashi predictive survival models. Morbidity and mortality rates concur with those in the medical literature. This study underscores the difficulty in utilizing metastatic spine scoring systems to predict patient survival. We believe a scoring system based on cancer type is needed to account for changes in treatment paradigms with improved patient survival over time.
Source: Journal of Spinal Disorders and Techniques - Category: Surgery Tags: Primary Research Source Type: research
Abstract Syndecan 2 (SDC2) belongs to a four‐member family of evolutionary conserved small type I transmembrane proteoglycans consisting of a protein core to which glycosaminoglycan chains are covalently attached. SDC2 is a cell surface heparan sulfate proteoglycan, which is increasingly drawing attention for its distinct characteristics and its participation in numerous cell functions, including those related to carcinogenesis. Increasing evidence suggests that the role of SDC2 in cancer pathogenesis is dependent on cancer tissue origin rendering its use as a biomarker/therapeutic target feasible. This mini review discu...
Source: IUBMB Life - Category: Research Authors: Tags: Critical Review Source Type: research
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