A very low incidence of BRAF mutations in Middle Eastern colorectal carcinoma

Conclusion:
Our results highlight the low incidence of BRAF mutations and CIMP in CRC from Saudi Arabia. This could be attributed to ethnic differences and warrant further investigation to elucidate the effect of other environmental and genetic factors. These findings indirectly suggest the possibility of a higher incidence of familial hereditary colorectal cancers especially Hereditary non polyposis colorectal cancer (HNPCC) syndrome /Lynch Syndrome (LS) in Saudi Arabia.

Source: Molecular Cancer - July 8, 2014 Category: Cancer & Oncology Authors: Abdul SirajRong BuSarita PrabhakaranPrashant BaviShaham BegMohsen Al HazmiMaha Al-RasheedKhadija AlobaisiFouad Al-DayelHadeel AlManeaNasser Al-SaneaShahab UddinKhawla Al-Kuraya Source Type: research