Gamida Cell launches severe aplastic anemia trial
Gamida Cell said today that the first patient has been transplanted in a study of its CordIn product for patients with severe aplastic anemia or hypoplastic myelodysplastic syndrome. The product is designed for patients with rare genetic diseases who have no fully-matched donors for a bone marrow transplantation. Gamida Cell said it is also evaluating its CordIn therapy for patients with sickle cell disease. Get the full story at our sister site, Drug Delivery Business News. The post Gamida Cell launches severe aplastic anemia trial appeared first on MassDevice.
Jun Hu, Lingli Chen, Yimei Tang, Chunlin Xie, Baoyang Xu, Min Shi, Wenyong Zheng, Shuyi Zhou, Xinkai Wang, Liu Liu, Yiqin Yan, Tao Yang, Yaorong Niu, Qiliang Hou, Xiaofan Xu, Xianghua Yan
Fecal microbiota transplantation can be used for the first-line treatment of C difficile, and it might also have an effect on neurologic and autoimmune diseases, such as autism and alopecia areata.Medscape Medical News
VITAMIN B12 deficiency can result in anaemia, but among its symptoms are headaches and a reduced appetite. The vitamin is vital in keeping the body in the best condition, but because the body doesn ’t make the vitamin it’s important to get it from a balanced diet. Here are six foods that are all good sources of B12.
Authors: Bodilsen J, Brouwer MC, Nielsen H, van de Beek D Abstract INTRODUCTION: Brain abscess is an uncommon and potentially life-threatening infection of the CNS that can be caused by a range of different pathogens including bacteria, fungi and parasites. A multidisciplinary approach is important and anti-infective treatment remains crucial. Here, we review anti-infective treatment of brain abscess. Areas covered: We used the terms '(Brain abscess[ti] AND (antibiotic* OR treatment)) NOT case report'), to conduct a search in the PubMed. Additional papers were identified by cross-reference checking and by browsing ...
Authors: Niemeyer P, Becher C, Buhs M, Fickert S, Gelse K, Günther D, Kaelin R, Kreuz P, Lützner J, Nehrer S, Madry H, Marlovits S, Mehl J, Ott H, Pietschmann M, Spahn G, Tischer T, Volz M, Walther M, Welsch G, Zellner J, Zinser W, Angele P Abstract Surgical principles for treatment of full-thickness cartilage defects of the knee include bone marrow stimulation techniques (i.e. arthroscopic microfracturing) and transplantation techniques (i.e. autologous chondrocyte implantation and osteochondral transplantation). On the basis of increasing scientific evidence, indications for these established therapeuti...
Authors: Pleines I, Cherpokova D, Bender M Abstract Megakaryocytes differentiate from hematopoietic stem cells in the bone marrow. The transition of megakaryocytes to platelets is a complex process. Thereby, megakaryocytes extend proplatelets into sinusoidal blood vessels, where the proplatelets undergo fission to release platelets. Defects in platelet production can lead to a low platelet count (thrombocytopenia) with increased bleeding risk. Rho GTPases comprise a family of small signaling G proteins that have been shown to be master regulators of the cytoskeleton controlling many aspects of intracellular process...
Conditions: Clostridium Difficile Infection Recurrence; Clostridium Difficile Infection Intervention: Procedure: Fecal Microbiota Transplantation Sponsor: University of Massachusetts, Worcester Recruiting
Conditions: Advanced Lung Disease; Lung Transplant; Extracorporeal Membrane Oxygenation Interventions: Device: MRP and NMES(neuromuscular electric stimulation); Other: Standard of Care Sponsor: University of Maryland Not yet recruiting
CONCLUSION: A high prevalence of iron overload in this patient population in Latin American countries indicates that a better diagnosis and management of iron overload is required in these countries. PMID: 29663858 [PubMed - as supplied by publisher]
We describe a case of SCD, in which a patient with high HbF level presented at a very late age (27 years old). We presume the patient’s inherently elevated HbF levels were able to compensate for the hypoxic episodes associated with SCD. The onset of symptoms was delayed as a result of elevated HbF levels.