MnAl-Layered Double Hydroxide Nanoparticles as a Dual-functional Platform for Magnetic Resonance Imaging and siRNA Delivery.

MnAl-Layered Double Hydroxide Nanoparticles as a Dual-functional Platform for Magnetic Resonance Imaging and siRNA Delivery. Chemistry. 2017 Aug 01;: Authors: Zuo H, Chen W, Li B, Xu K, Cooper H, Gu Z, Xu ZP Abstract Multifunctional nanoparticles for cancer theranosis have been widely explored for effective cancer detection and therapy. In this research, dually functionalised manganese-based layered double hydroxide nanoparticles (Mn-LDHs) have been examined as an effective anticancer drug/gene delivery system and T1-weighted magnetic resonance imaging (MRI) modality for brain cancer theranostics. Such Mn-LDHs have been shown to accommodate dsDNA/siRNAs and efficiently deliver to Neuro-2a cells (N2a). Mn-LDHs have also shown high biocompatibility with low cytotoxicity. Importantly, the cell death-siRNA (CD-siRNA) delivered with Mn-LDHs more efficiently kills brain cancer cells than the free CD-siRNA. Moreover, Mn-LDHs are noted to act as an excellent contrast agent for MRI, with the r1 value of 4.47 mM -1 s -1, higher than that of commercial Gd-based complex contrast agent (r1 = 3.4 mM -1 s -1). Altogether, the high delivery efficacy and MRI contrast capability demonstrate dual-functional Mn-LDHs as a potential agent for simultaneous cancer diagnosis and therapy. PMID: 28762580 [PubMed - as supplied by publisher]
Source: Chemistry - Category: Chemistry Authors: Tags: Chemistry Source Type: research