Oral versus intravenous fluoropyrimidines for colorectal cancer.

CONCLUSIONS: Results of this review should provide confidence that treatment for CRC with most of the oral fluoropyrimidines commonly used in current clinical practice is similarly efficacious to treatment with IV fluoropyrimidines. Treatment with eniluracil with oral 5-FU was associated with inferior PFS and OS among participants treated with palliative intent for CRC, and eniluracil is no longer being developed. Oral and IV fluoropyrimidines have different patterns of side effects; future research may focus on determining the basis for these differences. PMID: 28752564 [PubMed - as supplied by publisher]
Source: Cochrane Database of Systematic Reviews - Category: General Medicine Authors: Tags: Cochrane Database Syst Rev Source Type: research

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CONCLUSION: A significant association was observed between DPYD*9A polymorphism and CAPOX induced dose-limiting toxicities strengthening its role as a predictive biomarker. PMID: 31653159 [PubMed - in process]
Source: Asian Pacific Journal of Cancer Prevention - Category: Cancer & Oncology Tags: Asian Pac J Cancer Prev Source Type: research
ConclusionsAtezo + bev + cobi had an acceptable safety profile with manageable AEs with improved activity over that reported with SOC in 2L+ mCRC. A greater benefit trend was seen in pts with a RAS mutation vs wild-type tumours. Table:603P2L therapy (n  = 25)3L+ therapy (n = 24)Overall (N = 49)Confirmed response per RECIST 1.1, n (%)a2 (8%)2 (8%)4 (8%)mPFS (range), moa5.5 (3.6-9.4)5.8(2.4-9.0)5.5 (3.6-7.5)mOS (range), moNE(11.7-NE)11.8 (8.7-21.8)11.8 (9.0-21.8)RAS mutant (n  = 33)RAS wild-type/ unknown (n = 16)Pb HR (95% CI)DCR, n (%)c (95% CI)12 (36) (2...
Source: Annals of Oncology - Category: Cancer & Oncology Source Type: research
Dongyan Zhang1†, Hui Liu1†, Sixin Wang1, Wei Zhang1, Jing Wang1, Hongwu Tian2, Yamin Wang1 and Haifeng Ji1* 1Institute of Animal Husbandry and Veterinary Medicine, Beijing Academy of Agriculture and Forestry Sciences, Beijing, China 2Beijing Research Center of Intelligent Equipment for Agriculture, Beijing, China Lactobacillus has a positive effect on the host intestinal microbiota. In piglets, dietary supplementation with Lactobacillus affects general health and plays an important role in nutrient digestion and fermentation. However, this association requires further investigation. Here, we studie...
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
LITFL • Life in the Fast Lane Medical Blog LITFL • Life in the Fast Lane Medical Blog - Emergency medicine and critical care medical education blog aka Tropical Travel Trouble 004 A medical student who has just returned from their elective in Nepal presents with 1 week of bloody diarrhoea. He has been in the lowlands and stayed with a family in the local village he was helping at. It started three days before he left and he decided to get home on the plane in the hope it would settle. He is now opening his bowels 10x a day with associated cramps, fevers and has started feeling dizzy. Questions: Q1. What is dyse...
Source: Life in the Fast Lane - Category: Emergency Medicine Authors: Tags: Clinical Cases Tropical Medicine amoebic dysentery bacillary dysentery e.histolytica entamoeba histolytica shigellosis Source Type: blogs
This study aimed to investigate the prophylactic efficacy of Polaprezinc administered orally against intestinal mucositis induced by 5‐FU in mice on the condition that the anti‐tumour effect could not be compromised. We induced intestinal mucositis in SPF grade ICR mice with 5‐FU, and evaluated intestinal damage in the absence or presence of Polaprezinc. We examined the score of diarrhoea and the loss of weight following the 5‐FU treatment, and assessed the integrity of villus and the proliferation of small intestine crypt cells by Hematoxylin&Eosin staining and PCNA immunohistochemical detection. The anti‐tumour...
Source: Basic and Clinical Pharmacology and Toxicology - Category: Drugs & Pharmacology Authors: Tags: Original Article Source Type: research
This study aimed to investigate the prophylactic efficacy of Polaprezinc administered orally against intestinal mucositis induced by 5-FU in mice on the condition that the anti-tumour effect could not be compromised. We induced intestinal mucositis in SPF grade ICR mice with 5-FU, and evaluated intestinal damage in the absence or presence of Polaprezinc. We examined the score of diarrhoea and the loss of weight following the 5-FU treatment, and assessed the integrity of villus and the proliferation of small intestine crypt cells by Hematoxylin&Eosin staining and PCNA immunohistochemical detection. The anti-tumour effect of...
Source: Clinical Colorectal Cancer - Category: Cancer & Oncology Authors: Tags: Basic Clin Pharmacol Toxicol Source Type: research
This study showed dacomitinib induces severe ileal damage accompanied by increased MCP1 expression, and gastrointestinal permeability in rats. The histological changes were most pronounced in the ileum, which was also the region with the highest relative expression of ErbB1. This article is protected by copyright. All rights reserved.
Source: International Journal of Cancer - Category: Cancer & Oncology Authors: Tags: Research Article Source Type: research
Mainstream medicine wants you to believe the only thing you can do about diabetes is take Big Pharma’s pills or insulin shots for the rest of your life. Even if you’re not diabetic, all those carbs in your diet — cereal, pasta, potatoes, bread and sugary drinks — means your body is getting a dangerous overload of sugar. And it may be just a matter of time, before you become a statistic in America’s fastest growing health epidemic. For decades, I’ve been helping my patients not just manage their diabetes symptoms, also to reverse it for good. And I’ve also been helping them to preve...
Source: Al Sears, MD Natural Remedies - Category: Complementary Medicine Authors: Tags: Natural Cures diabetes guava Source Type: news
Abstract Background Gastrointestinal (GI) mucositis caused by chemotherapy is associated with diarrhoea and intestinal barrier disruption caused by apoptosis, immune dysfunction and microbiome alterations. Serum-derived bovine immunoglobulin/protein isolate (SBI) has been shown to manage HIV-associated enteropathy and irritable bowel syndrome with diarrhoea (IBS-D). We investigated in a rat model whether SBI was effective in alleviating symptoms of irinotecan-induced GI mucositis. Methods Animals were gavaged with 250 or 500 mg/kg of SBI twic...
Source: Supportive Care in Cancer - Category: Cancer & Oncology Source Type: research
Conclusion: Our study found irinotecan and capecitabine administered fortnightly with bevacizumab in patients with mCRC to be an effective and tolerable regimen.Trial registrationclinicaltrials.gov identifier NCT00875771. Trial registration date: 04/02/2009.
Source: Epidemiologic Perspectives and Innovations - Category: Epidemiology Authors: Source Type: research
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