Excellent response to Anti-PD-1 therapy in a patient with hepatocellular carcinoma: case report and review of literature.

We report a case of pseudoprogression followed by an excellent response in an HCC patient treated with nivolumab and review the literature for ongoing trials of immune checkpoint blockade in HCC. The pseudoprogression in our case is supported by increase in both tumor size and alpha-fetoprotein after four treatments with nivolumab; however, regression of tumor size and normalization of alpha-fetoprotein occurred after subsequent treatments. To our knowledge, there are no reports of pseudoprogression in HCC although pseudoprogression has been well described in melanoma. PMID: 28715649 [PubMed - in process]
Source: Discovery Medicine - Category: Research Tags: Discov Med Source Type: research