Cancer by remote-control: Overlooked DNA shuffling drives deadly paediatric brain tumour

One of the deadliest forms of paediatric brain tumor, Group 3 medulloblastoma, is linked to a variety of large-scale DNA rearrangements which all have the same overall effect on specific genes located on different chromosomes. "We were surprised to see that in addition to MYC there are two other major drivers of Group 3 medulloblastoma -- two sister genes called GFI1B and GFI1," says Korbel. "Our findings could be relevant for research on other cancers, as we discovered that those genes had been activated in a way that cancer researchers don't usually look for in solid tumors," researchers remarked.
Source: ScienceDaily Headlines - Category: Science Source Type: news