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Agent clears toxic proteins and improves cognition in neurodegeneration models

(Georgetown University Medical Center) Researchers have found cell receptors abnormally overexpressed in post-mortem brains of those with Parkinson's and Alzheimer's diseases, and that they can be inhibited in animal models to clear toxic protein buildup, reduce brain inflammation, and improve cognitive performance.
Source: EurekAlert! - Social and Behavioral Science - Category: International Medicine & Public Health Source Type: news

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Phys. Chem. Chem. Phys., 2018, Accepted Manuscript DOI: 10.1039/C7CP06838G, PaperReem A Karaballi, Soraya Merchant, Sasha R Power, Christa Lynn Brosseau Human diseases characterized by the uncontrolled deposition of insoluble extracellular protein aggregates are collectively referred to as amyloidoses. Such diseases include Alzheimer's, Parkinson's, Huntington's, and prion disease. In Alzheimer's disease,... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Phys. Chem. Chem. Phys. latest articles - Category: Chemistry Authors: Source Type: research
This study revealed the effect of phenolic extract from Hibiscus sabdariffa L. (sorrel) calyx on acetylcholinesterase (AChE), butyrylcholinesterase (BChE), monoamine oxidase (MAO), and ecto-5' nucleotidase (E-NTDase) activities as well as pro-oxidant-induced oxidative damage in rat brain in vitro. Sorrel extract inhibited AChE (EC50 = 46.96 µg/mL), BChE (EC50 = 40.38 µg/mL), MAO (EC50 = 43.69 µg/mL), and E-NTDase (EC50 = 40.52 µg/mL) and stimulated Na+/K+-ATPase (EC50 = 22.01 µg/mL) activities. The phenolic extract also reduced Fe2+- (EC50 = 22.37 µg/mL) and...
Source: Journal of Dietary Supplements - Category: Nutrition Tags: J Diet Suppl Source Type: research
Loss of the sense of smell is among the first signs of natural aging and neurodegenerative diseases such as Alzheimer's and Parkinson's. Cellular and molecular mechanisms promoting this smell loss are not understood. Here, we show thatDrosophila melanogaster also loses olfaction before vision with age. Within the olfactory circuit, cholinergic projection neurons show a reduced odor response accompanied by a defect in axonal integrity and reduction in synaptic marker proteins. Using behavioral functional screening, we pinpoint that expression of the mitochondrial reactive oxygen scavenger SOD2 in cholinergic projection neur...
Source: eLife - Category: Biomedical Science Tags: Neuroscience Source Type: research
OBJECTIVE: The prevalence of Alzheimer's disease and Parkinson's disease increases with the raising number of elderly, which will be a challenging situation for the healthcare systems and society in the future. There is evidence that there are modifiable r...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Elder Adults Source Type: news
Wednesday at 1:30 p.m., the Jacksonville Business Journal will sit down in a Facebook Live interview with the minds behind NeuroInitiative, a Jacksonville company trying to accelerate the path to treating Parkinson's disease and Alzheimers. Co-founders Spring Behrouz and Andy Lee will share the vision behind their company and how their custom-built, virtual brain cell can be used to test treatments rapidly and cost-effectively. Behrouz, a neuroscientist, serves as CEO, and Lee, a software engineer…
Source: bizjournals.com Health Care:Biotechnology headlines - Category: Biotechnology Authors: Source Type: news
Drugs that disrupt production of toxic proteins in the brain could work for various degenerative disorders, including Alzheimer’s and Parkinson’s  -- Read more on ScientificAmerican.com
Source: Scientific American - Category: Science Authors: Tags: Health Medicine Mind Cognition Neurological Health Neuroscience Source Type: research
Focus on Neuro Diseases We now have the capability to provide cells of the central and peripheral nervous system from donors with Neuro diseases. These include cells from donors with ALS, AD, PD, and Brain Cancer Donors, to name a few.We have provided cells to virtually all the large Pharmas and many small and mid-size Bio-techs. We have worked with Novartis to gain 21-CFR compliance for cells that they are using for their eye diseases drug discovery programs.I am at your “beck and call” should you have interested in exploring specific capabilities further. You can e-mail or call me at 612-801-1007
Source: Neuromics - Category: Neuroscience Tags: 3-D Cell based Assays ALS Alzheimer ' s Disease Amyotrophic Lateral Sclerosis glioblastomas Parkinson Source Type: news
AbstractPurpose of ReviewAlthough the cholinergic hypothesis of dementia provided a successful paradigm for the development of new drugs for dementia, this hypothesis has waned in popularity. Cholinergic brain imaging may provide novel insights into the viability of this hypothesis.Recent FindingsCholinergic receptor and forebrain volumetric studies suggest an important role of the cholinergic system in maintaining brain network integrity that may deteriorate with cognitive decline in Alzheimer disease (AD) and Lewy body disorders (LBD). Bidirectional changes in regional receptor expression may suggest the presence of comp...
Source: Current Geriatrics Reports - Category: Geriatrics Source Type: research
"Understanding the Role of Hypoxia inducible factor during neurodegeneration for new therapeutics opportunities". Curr Neuropharmacol. 2018 Jan 10;: Authors: Merelli A, Rodriguez JCG, Folch J, Regueiro MR, Camins A, Alberto L Abstract Neurodegeneration (NDG) is linked with the progressive loss of neural function with intellectual and/or motor impairment. Several diseases affecting older individuals, including Alzheimer's disease, Amyotrophic Lateral Sclerosis, Huntington's disease, Parkinson's disease, stroke, Multiple Sclerosis and many others, are the most relevant disorders associated wit...
Source: Current Neuropharmacology - Category: Drugs & Pharmacology Authors: Tags: Curr Neuropharmacol Source Type: research
Publication date: Available online 2 January 2018 Source:Neurochemistry International Author(s): Hideki Mochizuki, Chi-Jing Choong, Eliezer Masliah α-synuclein (αSyn) still remains a mysterious protein even two decades after SNCA encoding it was identified as the first causative gene of familial Parkinson's disease (PD). Accumulation of αSyn causes α-synucleinopathies including PD, dementia with Lewy bodies (DLB) and multiple system atrophy (MSA). Recent advances in therapeutic approaches offer new antibody-, vaccine-, antisense-oligonucleotide- and small molecule-based options to reduce αSyn...
Source: Neurochemistry International - Category: Neuroscience Source Type: research
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