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Agent clears toxic proteins and improves cognition in neurodegeneration models

(Georgetown University Medical Center) Researchers have found cell receptors abnormally overexpressed in post-mortem brains of those with Parkinson's and Alzheimer's diseases, and that they can be inhibited in animal models to clear toxic protein buildup, reduce brain inflammation, and improve cognitive performance.
Source: EurekAlert! - Social and Behavioral Science - Category: International Medicine & Public Health Source Type: news

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Authors: Kolnagou A, Kontoghiorghe CN, Kontoghiorghes GJ Abstract Millions of people worldwide suffer from iron overload toxicity diseases such as transfusional iron overload in thalassaemia and hereditary haemochromatosis. The accumulation and presence of toxic focal iron deposits causing tissue damage can also be identified in Friedreich's ataxia, Alzheimer's, Parkinson's, renal and other diseases. Different diagnostic criteria of toxicity and therapeutic interventions apply to each disease of excess or misplaced iron. Magnetic resonance imaging relaxation times T2 and T2* for monitoring iron deposits in organs a...
Source: Frontiers in Bioscience - Scholar - Category: Biomedical Science Tags: Front Biosci (Schol Ed) Source Type: research
In this study, quantitative phosphoproteomic profiling together with a computational analysis was performed to delineate the phosphorylation signalling networks regulated by 2 natural neuroprotective autophagy enhancers, corynoxine (Cory) and corynoxine B (Cory B). To identify key regulators, namely, protein kinases, we developed a novel network-based algorithm of in silico Kinome Activity Profiling (iKAP) to computationally infer potentially important protein kinases from phosphorylation networks. Using this algorithm, we observed that Cory or Cory B potentially regulated several kinases. We predicted and validated that C...
Source: Autophagy - Category: Cytology Authors: Tags: Autophagy Source Type: research
Conclusions These studies have shown that dietary n-3 PUFA treatments consistently improve cognitive performance in animal models and may also exert disease-modifying actions. N-3 PUFA also provide protection to dopaminergic neurons in animal models of PD and possibly recovery after lesion. Furthermore, some of these effects might depend on specific diet formulations to protect long-chain fatty acids from oxidation or synergies with other nutrients. More generally, this review aims at providing evidence that adjustments in the consumption of dietary lipids alone or combined with other nutrients may be a cost-effective inte...
Source: Trends in Food Science and Technology - Category: Food Science Source Type: research
Date: September 25, 2017 Issue #:  1530Summary:  View the Comparison Table: Drugs for Alzheimer's Disease
Source: The Medical Letter - Category: Drugs & Pharmacology Authors: Tags: Alzheimer ' s disease Aricept Donepezil Exelon Galantamine Memantine Namenda Namzaric Parkinson Razadyne Rivastigmine Source Type: research
Date: September 25, 2017 Issue #:  1530Summary:  View the Comparison Table: Drugs for Alzheimer's Disease
Source: The Medical Letter - Category: Drugs & Pharmacology Authors: Tags: Alzheimer ' s disease Aricept Donepezil Exelon Galantamine Memantine Namenda Namzaric Parkinson Razadyne Rivastigmine Source Type: research
Publication date: Available online 17 September 2017 Source:The Lancet Neurology Author(s): GBD 2015 Neurological Disorders Collaborator GroupValery LFeiginAmanuel AlemuAbajobirKalkidan HassenAbateFoadAbd-AllahAbdishakur MAbdulleSemaw FeredeAberaGebre YitayihAbyuMuktar BeshirAhmedAmani NidhalAichourIbtihelAichourMiloud Taki EddineAichourRufus OlusolaAkinyemiSamerAlabedRajaaAl-RaddadiNelsonAlvis-GuzmanAzmeraw T.AmareHosseinAnsariPalwashaAnwariJohanÄrnlövHamidAsayeshSolomon WeldegebrealAsgedomTesfay MehariAteyLeticiaAvila-BurgosEuripideFrinelG. ArthurAvokpahoAleksandraBaracMiguelBarbozaSuzanne LBarker-ColloTillB&a...
Source: The Lancet Neurology - Category: Neurology Source Type: research
Activated microglial cells produce the pro-inflammatory mediators such as nitric oxide (NO) and cytokines. The excessive release of these mediators can lead to neurodegenerative diseases, such as Alzheimer's disease (AD) and Parkinson's disease (PD). Inhibition of the release of these pro-inflammatory molecules may prevent or halt the progression of these diseases. Plumbagin (PL), a naphthoquinone compound in the roots of the traditional medicinal plant Plumbago zeylanica L., showed anti-inflammatory effects on macrophages.
Source: Journal of Neuroimmunology - Category: Allergy & Immunology Authors: Source Type: research
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Source: Journal of Cellular Physiology - Category: Cytology Authors: Tags: REVIEW ARTICLE Source Type: research
Abstract Muscarinic acetylcholine receptors are G protein-coupled receptors (GPCRs) which are broadly expressed in the central nervous system (CNS) and other tissues in the periphery. They emerge as important drug targets for a number of diseases including Alzheimer's disease, Parkinson's disease, and schizophrenia. Muscarinic receptors are divided into five subtypes (M1-M5) of which M1-M4 have been crystalized. All subtypes possess at least one allosteric binding site which is located in the extracellular region of the receptor on top of the ACh (i.e. orthosteric) binding site. The former can be specifically targ...
Source: Neuropharmacology - Category: Drugs & Pharmacology Authors: Tags: Neuropharmacology Source Type: research
Authors: Elufioye TO, Berida TI, Habtemariam S Abstract Neuroprotection is the preservation of the structure and function of neurons from insults arising from cellular injuries induced by a variety of agents or neurodegenerative diseases (NDs). The various NDs including Alzheimer's, Parkinson's, and Huntington's diseases as well as amyotropic lateral sclerosis affect millions of people around the world with the main risk factor being advancing age. Each of these diseases affects specific neurons and/or regions in the brain and involves characteristic pathological and molecular features. Hence, several in vitro and ...
Source: Evidence-based Complementary and Alternative Medicine - Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research
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