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Noggin Along with a Self-Assembling Peptide Nanofiber Containing Long Motif of Laminin Induces Tyrosine Hydroxylase Gene Expression

AbstractTyrosine hydroxylase (TH), a rate-limiting step in catecholamine synthesis in which its activity influences Alzheimer disease, Parkinson disease, and IQ of schizophrenia patients, has been studied for a long time. In the meantime, the present investigation assessed the effect of noggin and type of self-assembling nanofibers in TH gene over-expression by neuron-like cells derived from human endometrial-derived stromal cells (hEnSCs). Neuroblastoma cells and hEnSCs encapsulated into nanofibers including Matrigel, (RADA)4, laminin, and BMHP-1 motif bounded to (RADA)4 and their cell viability were studied for 48  h and 18 days in basal and neurogenic media, respectively, in noggin-rich media. Then, expression of neural genes and proteins has been investigated by immunocytochemistry (ICC) and real-time PCR methods, respectively. The results indicated that neuroblastoma cell and hEnSC viability is in good a greement with the level of Bcl2 and β-tubulin III gene expression; however, -BMHP-1 and -laminin nanofibers exhibited significantly higher cell viability eventually through Wnt/β-catenin signaling pathway as compared to others, respectively. The gene expression analysis of nanofibers showed that n one of them induced gamma-aminobutyric acid (GABA) gene expression while glial fibrillary acidic protein (GFAP) gene just over-expressed in cells encapsulated into Matrigel with a low level of Bcl2 gene expression. However, the TH gene just had been over-exp...
Source: Molecular Neurobiology - Category: Neurology Source Type: research

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CONCLUSION: Chinese familial caregivers of patients with dementia experience a moderate level of burden and a high level of strain. The main strain factors that affected the burden were changes in personal plans, time demands, and emotional adjustment. PMID: 29775139 [PubMed - in process]
Source: Issues in Mental Health Nursing - Category: Nursing Tags: Issues Ment Health Nurs Source Type: research
CONCLUSIONS: MicroRNA-377 could regulate the expression level of CDH13 by promoting cell proliferation and inhibiting cell apoptosis, thus participating in the occurrence of the Alzheimer's disease. PMID: 29771432 [PubMed - in process]
Source: European Review for Medical and Pharmacological Sciences - Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research
Authors: Liu J, Wang WM, Zhang XL, Du QH, Li HG, Zhang Y Abstract OBJECTIVE: To investigate the expression of lncRNA neuroblastoma associated transcript 1 (NBAT1) in human glioma cell lines and its underlying mechanism. Effect of NBAT1 on biological behaviors of T98 and U87 cells are also explored. PATIENTS AND METHODS: The mRNA expressions of NBAT1 in 48 cases of glioblastoma tissues and 30 cases of normal brain tissues were accessed by Real-time fluorescence quantitative PCR (RT-PCR). The relationship between mRNA expression of NBAT1 and tumor size, malignancy, and prognosis were analyzed. Effects of NBAT1 on...
Source: European Review for Medical and Pharmacological Sciences - Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research
Publication date: Available online 18 May 2018 Source:Neuroscience & Biobehavioral Reviews Author(s): Melissa M. Conti, Nicole Chambers, Christopher Bishop Traditionally, dopamine (DA) and acetylcholine (ACh) striatal systems were considered antagonistic and imbalances or aberrant signaling between these neurotransmitter systems could be detrimental to basal ganglia activity and pursuant motor function, such as in Parkinson’s disease (PD) and L-DOPA-induced dyskinesia (LID). Herein, we discuss the involvement of cholinergic interneurons (ChIs) in striatally-mediated movement in a healthy, parkinsonian, and dyski...
Source: Neuroscience and Biobehavioral Reviews - Category: Neuroscience Source Type: research
An international research team funded by the MRC, and led by scientists at the University of Edinburgh and the University of Queensland, has identified three new genes linked to the risk of Alzheimer’s disease.
Source: Medical Research Council General News - Category: Research Source Type: news
Insightec said this week it submitted an application for pre-market approval to the Japanese Pharmaceuticals and Medical Devices Agency seeking an indication for its Exablate Neuro to treat advanced Parkinson’s Disease in patients suffering from mobility, rigidity or dyskinesia. The Israel-based company’s Exablate Neuro device uses high-intensity, focused ultrasound to thermally ablate targeted tissue, guided by continuous magnetic resonance imaging; the procedure can be performed non-invasively through an intact skull. “Insightec is committed to supporting research that extends the applica...
Source: Mass Device - Category: Medical Devices Authors: Tags: Neurological Regulatory/Compliance Ultrasound INSIGHTEC Source Type: news
This study] helps to further solidify CSC [coordinated specialty care] as a standard of care for young people with the recent onset of a psychotic illness,” Nossel toldPsychiatric News. “Often young people with psychosis or schizophrenia may be hesitant to engage in treatment or may not believe they have an illness. The CSC approach is to meet people where they are, use a shared decision-making approach, and help people achieve the goals that are important to them.”For related information, see thePsychiatric News article “Participation in Early Psychosis Program May Reduce Risk of Death. ”(Ima...
Source: Psychiatr News - Category: Psychiatry Tags: coordinated specialty care early intervention Global Assessment of Functioning Ilana Nossel OnTrackNY Psychiatric Services in Advance psychosis Source Type: research
(Reuters) - Johnson and Johnson said it would stop mid-stage trials testing its experimental Alzheimer's drug after observing safety issues, the latest drugmaker to abandon developing treatments for the memory-robbing disease.
Source: Reuters: Health - Category: Consumer Health News Tags: healthNews Source Type: news
The worst part of being a caregiver for a person living with dementia is that you seldom get much real help from family.By Donna StClairAlzheimer's Reading RoomTime and again I have heard the same refrain:the worst part of being a caregiver is that you seldom get much real help from family and close friends who should be able to pony up and provide just a smidgen of assistance.I ’ve got something worse than worst.Instead of help and assistance, I get criticism.Learn More -Dementia care why won't family helpSubscribe to the Alzheimer's Reading - This is a Free Service - Join NowHave you ever heard these words?Why aren...
Source: Alzheimer's Reading Room, The - Category: Neurology Tags: alzheimer's caregiver alzheimer's caregiver support Alzheimer's Dementia alzheimer's new s care of dementia patients dementia care dementia care why won't family help dementia family Source Type: blogs
AbstractRestoring neurotransmitter acetylcholine (ACh) levels by inhibiting acetylcholinesterase (AChE) has become the primary treatment for the cognitive deficits of Alzheimer ’s disease. The inhibitory effects of flavonoids on AChE have attracted great interest among researchers, but few reports have focused on the interaction characteristics of inhibitor with AChE. In this work, the interaction of inhibitor baicalin with AChE was studied for the first time by fluoresc ence spectroscopy coupled with UV spectroscopy and circular dichroism (CD) techniques under near physiological conditions. The fluorescence quenchin...
Source: Medicinal Chemistry Research - Category: Chemistry Source Type: research
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