Macrophage migration inhibitory factor: A multifaceted cytokine implicated in multiple neurological diseases.

Macrophage migration inhibitory factor: A multifaceted cytokine implicated in multiple neurological diseases. Exp Neurol. 2017 Jul 02;: Authors: Leyton-Jaimes MF, Kahn J, Israelson A Abstract Macrophage migration inhibitory factor (MIF) is a conserved cytokine found as a homotrimer protein. It is found in a wide spectrum of cell types in the body including neuronal and non-neuronal cells. MIF is implicated in several biological processes; chemo-attraction, cytokine activity, and receptor binding, among other functions. More recently, a chaperone-like activity has been added to its repertoire. In this review, we focus on the implication of MIF in the central nervous system and peripheries, its role in neurological disorders, and the mechanisms by which MIF is regulated. Numerous studies have associated MIF with various disease settings. MIF plays an important role in advocating tumorigenic processes, Alzheimer's disease, and is also upregulated in autism-spectrum disorders and spinal cord injury where it contributes to the severity of the injured area. The protective effect of MIF has been reported in amyotrophic lateral sclerosis by its reduction of aggregated misfolded SOD1, subsequently reducing the severity of this disease. Interestingly, a protective as well as pathological role for MIF has been implicated in stroke and cerebral ischemia, as well as depression. Thus, the role of MIF in neurological disorders appears to be diverse with both beneficial...
Source: Experimental Neurology - Category: Neurology Authors: Tags: Exp Neurol Source Type: research

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Source: Jornal Brasileiro de Psiquiatria - Category: Psychiatry Source Type: research
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Source: Jornal Brasileiro de Psiquiatria - Category: Psychiatry Source Type: research
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Source: Jornal Brasileiro de Psiquiatria - Category: Psychiatry Source Type: research
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Source: Life Sciences - Category: Biology Source Type: research
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Source: Neurotoxicology and Teratology - Category: Toxicology Source Type: research
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Source: Preventive Medicine - Category: International Medicine & Public Health Source Type: research
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