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Improvement of Anti-malarial Artemisinin and Essential Oil Production in Response to Optimization of Irrigation and Nitrogen Supply to Artemisia annua L. Plant

The objective of study was to describe how plant biomass, essential oil production and anti-malarial artemisinin accumulation can be enhanced through irrigation and nitrogen fertilization. Materials and Methods: A field experiment was carried out during 2012 and 2013 seasons to determine biomass yield, essential oil and artemisinin content of German Artemisia under water stress (2, 3 and 4 weeks irrigation intervals) and nitrogen fertilization (30, 45 and 60 kg N/fed = 0.42 ha). Irrigation intervals and nitrogen rates were laid out in strip-plot design with three replicates. The obtained data were used to determine optimal irrigation interval and nitrogen rate. Statistical analysis was performed based on a strip-plot arrangement in a randomized complete block design. Results: Prolonging irrigation intervals up to 4 weeks significantly decreased (p
Source: Research Journal of Medicinal Plant - Category: Complementary Medicine Source Type: research

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(The Francis Crick Institute) Researchers have discovered crucial new processes that allow malaria parasites to escape red blood cells and infect other cells, offering potential new treatment targets. The team are already working with pharmaceutical companies to use this knowledge to develop new antimalarial drugs - a critical step in the battle against drug-resistant malaria.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news
This study explores a community-based approach to treating malaria case contacts.Methods/designThis is a cluster-randomized trial to determine whether, in low-transmission areas, treating individuals living in the same compound of a clinical malaria case with dihydroartemisinin-piperaquine  can reduce parasite carriage and thus residual malaria transmission. Treatment will be administered through the local health system with the approach of encouraging community participation designed and monitored through formative research. The trial goal is to show that this approach can reduce in intervention villages the prevalen...
Source: Trials - Category: Research Source Type: clinical trials
This study aimed to investigate the spatial association between malaria occurrence and environmental risk fac...
Source: Malaria Journal - Category: Infectious Diseases Authors: Tags: Research Source Type: research
Publication date: Available online 8 February 2018 Source:Ticks and Tick-borne Diseases Author(s): Jingwei Huang, Kang Xiong, Houshuang Zhang, Yanzhen Zhao, Jie Cao, Yongzhi Zhou, Haiyan Gong, Jinlin Zhou The intra-erythrocytic apicomplexan Babesia microti is the predominant pathogen that causes human babesiosis, an infectious disease that occurs worldwide. B. microti relies on the antioxidant including thioredoxin system to maintain the redox balance during the erythrocytic stage. In the present study, the full-length B. microti thioredoxin 3 (BmTrx3) gene was cloned, expressed in vitro, and its response to antiprotozoal...
Source: Ticks and Tick borne Diseases - Category: Zoology Source Type: research
Malaria is still one of the serious public health problems in Grande Comore Island, although the number of annual cases has been greatly reduced in recent years. A better understanding of malaria parasite popu...
Source: Malaria Journal - Category: Infectious Diseases Authors: Tags: Research Source Type: research
This study assessed the effect of co-administration of artemisinin andRicinodendron heudelotii extract on certain liver and antioxidant indices in rats. Four groups containing ten rats each were administered distilled water (group A), artemisinin only (group B), artemisinin withR.heudelotii extract (group C), andR.heudelotii extract only (group D). Serum biochemical values and antioxidant parameters were determined using standard methods respectively. The results revealed that the total protein level increased significantly (p 
Source: Comparative Clinical Pathology - Category: Pathology Source Type: research
Conclusions: Alpha-thalassemia trait is associated with high level ofP.vivax parasitemia in malaria patients in Southeast Asia.  
Source: Mediterranean Journal of Hematology and Infectious Diseases - Category: Hematology Source Type: research
Conclusions: Alpha-thalassemia trait is associated with high level ofP.vivax parasitemia in malaria patients in Southeast Asia.  
Source: Mediterranean Journal of Hematology and Infectious Diseases - Category: Hematology Source Type: research
Abstract Pathogens can release extracellular vesicles (EVs) for cell–cell communication and host modulation. EVs from Plasmodium falciparum, the deadliest malaria parasite species, can transfer drug resistance genes between parasites. EVs from late‐stage parasite‐infected RBC (iRBC‐EVs) are immunostimulatory and affect endothelial cell permeability, but little is known about EVs from early stage iRBC. We detected the parasite virulence factor PfEMP1, which is responsible for iRBC adherence and a major contributor to disease severity, in EVs, only up to 12‐hr post‐RBC invasion. Furthermore, using PfEMP1 tran...
Source: Cellular Microbiology - Category: Microbiology Authors: Tags: RESEARCH ARTICLE Source Type: research
A prior post listed 7 assertions regarding the role of infectious organisms on the human genome. In the next few blogs we'll look at each assertion, in excerpts fromPrecision Medicine and the Reinvention of Human Disease. Here's the seventh:By dissecting the biological steps involved in the pathogenesis of infectious disease, it is possible to develop new treatments, other than antibiotics, that will be effective against a range of related organisms. Nature, by interfering with the different steps in the development of infectious diseases, has a variety of protective mechanisms against organisms. For example, to defend aga...
Source: Specified Life - Category: Information Technology Tags: biological steps infections disease pathogenesis precision medicine Source Type: blogs
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