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Improvement of Anti-malarial Artemisinin and Essential Oil Production in Response to Optimization of Irrigation and Nitrogen Supply to Artemisia annua L. Plant

The objective of study was to describe how plant biomass, essential oil production and anti-malarial artemisinin accumulation can be enhanced through irrigation and nitrogen fertilization. Materials and Methods: A field experiment was carried out during 2012 and 2013 seasons to determine biomass yield, essential oil and artemisinin content of German Artemisia under water stress (2, 3 and 4 weeks irrigation intervals) and nitrogen fertilization (30, 45 and 60 kg N/fed = 0.42 ha). Irrigation intervals and nitrogen rates were laid out in strip-plot design with three replicates. The obtained data were used to determine optimal irrigation interval and nitrogen rate. Statistical analysis was performed based on a strip-plot arrangement in a randomized complete block design. Results: Prolonging irrigation intervals up to 4 weeks significantly decreased (p
Source: Research Journal of Medicinal Plant - Category: Complementary Medicine Source Type: research

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Authors: Belachew EB Abstract Malaria causes approximately 212 million cases and 429 thousand deaths annually. Plasmodium falciparum is responsible for the vast majority of deaths (99%) than others. The virulence of P. falciparum is mostly associated with immune response-evading ability. It has different mechanisms to evade both Anopheles mosquito and human host immune responses. Immune-evading mechanisms in mosquito depend mainly on the Pfs47 gene that inhibits Janus kinase-mediated activation. Host complement factor also protects human complement immune attack of extracellular gametes in Anopheles mosquito midgut...
Source: Journal of Immunology Research - Category: Allergy & Immunology Tags: J Immunol Res Source Type: research
(University of California - Riverside) A team of researchers led by a University of California, Riverside, scientist has found that various stages of the development of human malaria parasites, including stages involved in malaria transmission, are linked to epigenetic features and how chromatin -- the complex of DNA and proteins within the nucleus -- is organized and structured in these parasites.
Source: EurekAlert! - Infectious and Emerging Diseases - Category: Infectious Diseases Source Type: news
ConclusionsMalaria parasite infection significantly decreases the number of myeloblasts and inhibits neoplasm proliferation in mice. In addition, malaria parasite infection inhibits murine leukaemia by promoting immune responses.
Source: Infectious Diseases of Poverty - Category: Infectious Diseases Source Type: research
While flu season is drawing to a close, transmission of germs can still lead to colds and serious respiratory diseases. In few places are individuals more exposed to a multitude of unique germs and germ carriers than during travel. Unlike some forms ...
Source: Medgadget - Category: Medical Devices Authors: Tags: Exclusive Medicine Public Health Source Type: blogs
Abstract By 2050 our civilized planet may be comprised predominantly of networked megacities embedded in warm subtropical and tropical climates, and under stress from climate change and catastrophic weather events. Urban slum areas in these cities, including those found in wealthier middle- and high-income nations (blue marble health), will be especially vulnerable to disease. Moreover, regional conflicts fought over shifting and limited resources, including water, will collapse health systems infrastructures to further promote disease emergence and reemergence. Thus while by 2050 we might congratulate ourselves f...
Source: Advances in Parasitology - Category: Parasitology Authors: Tags: Adv Parasitol Source Type: research
The development of new treatments against schistosomiasis is imperative but lacks commercial interest. Drug repurposing represents a suitable strategy to identify potential treatments, which have already unblo...
Source: Parasites and Vectors - Category: Microbiology Authors: Tags: Research Source Type: research
In this study, the heme was biologically synthesized and polymerized by Corynebacterium glutamicum and final polymer was applied as a biomimetic conductive biopolymer. The biosynthesized monomer heme by metabolic engineered strain was enzymatically polymerized by an enzyme complex containing two different heme polymerization proteins. Moreover, the electrical conductivities of hemozoin prepared by heme polymerase enzyme complexes were investigated and compared with those of the heme monomer. Because of the synergetic effects of polymerized heme, synthesized artificial nanocrystals exhibited a greater conductive property th...
Source: Biosensors and Bioelectronics - Category: Biotechnology Source Type: research
Malaria is a deadly parasitic disease that affects more than 3 billion people worldwide, in predominantly resource-poor countries. Despite malaria being preventable and treatable, a large number of adults and ...
Source: BMC Public Health - Category: Consumer Health News Authors: Tags: Debate Source Type: research
ConclusionsOur results show that in low transmission settings, naturally acquired antibody responses against the CSP repeats ofP. vivax,P. falciparum, andP. malariae in a single cross-sectional study may not represent a valuable marker for monitoring recent malaria exposure, especially in an area with a high prevalence ofP. vivax. Furthermore, HLA class II molecules play an important role in antibody response and require further study with a larger sample size. It will be of interest to consider HLA analysis when using serosurveillance to monitor malaria exposure among genetically diverse populations.
Source: Infectious Diseases of Poverty - Category: Infectious Diseases Source Type: research
Abstract Important strides have been made within the past decade toward malaria elimination in many regions, and with this progress, the feasibility of eradication is once again under discussion. If the ambitious goal of eradication is to be achieved by 2040, all species of Plasmodium infecting humans will need to be targeted with evidence-based and concerted interventions. In this perspective, the potential barriers to achieving global malaria elimination are discussed with respect to the related diversities in host, parasite, and vector populations. We argue that control strategies need to be reorientated from a...
Source: The American Journal of Tropical Medicine and Hygiene - Category: Tropical Medicine Authors: Tags: Am J Trop Med Hyg Source Type: research
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