Improvement of Anti-malarial Artemisinin and Essential Oil Production in Response to Optimization of Irrigation and Nitrogen Supply to Artemisia annua L. Plant

The objective of study was to describe how plant biomass, essential oil production and anti-malarial artemisinin accumulation can be enhanced through irrigation and nitrogen fertilization. Materials and Methods: A field experiment was carried out during 2012 and 2013 seasons to determine biomass yield, essential oil and artemisinin content of German Artemisia under water stress (2, 3 and 4 weeks irrigation intervals) and nitrogen fertilization (30, 45 and 60 kg N/fed = 0.42 ha). Irrigation intervals and nitrogen rates were laid out in strip-plot design with three replicates. The obtained data were used to determine optimal irrigation interval and nitrogen rate. Statistical analysis was performed based on a strip-plot arrangement in a randomized complete block design. Results: Prolonging irrigation intervals up to 4 weeks significantly decreased (p
Source: Research Journal of Medicinal Plant - Category: Complementary Medicine Source Type: research

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uez P Abstract The binding of malaria pigment, hemozoin, by a gradient magnetic field has been investigated in a manual trapping column system. Two types of magnetic filling have been tested to produce field gradients: nickel-plated steel wires, wrapped around a steel core, and superparamagnetic microbeads. The latter system allows an efficient trapping (> 80%) of β-hematin (a synthetic pigment with physical and paramagnetic properties analogous to those of hemozoin). Tests with a Plasmodium falciparum 3D7 culture indicate that hemozoin is similarly trapped. Off-line optical spectroscopy measurements pre...
Source: Talanta - Category: Chemistry Authors: Tags: Talanta Source Type: research
The positioning of chromosomes in the nucleus of a eukaryotic cell is highly organized and has a complex and dynamic relationship with gene expression. In the human malaria parasite Plasmodium falciparum, the clustering of a family of virulence genes correlates with their coordinated silencing and has a strong influence on...
Source: Proceedings of the National Academy of Sciences - Category: Science Authors: Tags: PNAS Plus Source Type: research
The malaria burden of Myanmar still remains high within the Greater Mekong Subregion of Southeast Asia. An important indicator of progress towards malaria elimination is the prevalence of parasite infections i...
Source: Parasites and Vectors - Category: Microbiology Authors: Tags: Research Source Type: research
ConclusionsAdded to community-based basic malaria control measures, 3 monthly rounds of DP MDA reduced the incidence and prevalence of falciparum malaria over a 1-year period in areas affected by artemisinin resistance.P.falciparum infections returned during the follow-up period as the remaining infections spread and malaria was reintroduced from surrounding areas. Limitations of this study include a relatively small sample of villages, heterogeneity between villages, and mobility of villagers that may have limited the impact of the intervention. These results suggest that, if used as part of a comprehensive, well-organise...
Source: PLoS Medicine - Category: Internal Medicine Authors: Source Type: research
ConclusionsThe intervention tools available currently can most likely reduce transmission but clearing of malaria epicentres from where the disease can flare up any time, is not possible without involving local population. Nevertheless maintaining zero malaria transmission and checks on malaria import in declared malaria free countries, and further speeding up of interventions to stop transmission in elimination countries is most desirable. Strong collaboration backed by adequate political and financial support among the countries with a common objective to eliminate malaria must be on top priority. The present review atte...
Source: Infectious Diseases of Poverty - Category: Infectious Diseases Source Type: research
Abstract Malaria infection has posed a major health threat for hundreds of years in human history. Yet, due to the complex interactions between a host immune response and the parasite, no sophisticated mathematical models exist to study its dynamics. In this work, we propose a new system of structured partial differential equations that account for the dependence of red blood cell infectivity on maturation level. These equations are coupled with another set of differential equations for investigating the population dynamics of Plasmodium falciparum and its interaction with red blood cells and cells of the immune s...
Source: Mathematical Biosciences - Category: Statistics Authors: Tags: Math Biosci Source Type: research
Abstract Microscopic examination of blood smears is the standard method for malaria diagnosis but is labor-intensive and requires expert staff. CellaVision DM96 (CellaVision, Lund, Sweden) is a digital hematology analyzer available for advanced morphological analysis of blood films including intracellular parasites. Here, we evaluated the CellaVision DM96 Advanced RBC Application for malaria detection in stained peripheral blood (PB) smears. Two hundred and twenty thin PB smear slides (84 P. vivax, 14 P. falciparum, 122 negative controls) were stained with Wright-Giemsa using automated slidemaker/strainers of Beck...
Source: Acta Tropica - Category: Infectious Diseases Authors: Tags: Acta Trop Source Type: research
Contributors : Juliana M S á ; Sarah R Kaslow ; Michael A Krause ; Viviana Melendez-Muniz ; Rebecca E Salzman ; Whitney A Kite ; Min Zhang ; Roberto R Moraes Barros ; Jianbing Mu ; Paul K Han ; J P Mershon ; Christine E Figan ; Ramoncito L Caleon ; Tyler J Gibson ; Chanaki Amaratunga ; Theresa Engels ; Soundarapandian Velmurugan ; Stacy Ricklefs ; Judith Straimer ; Nina Gnädig ; Bingbing Deng ; Anna Liu ; Ababacar Diouf ; Kazutoyo Miura ; Gregory S Tullo ; Richard T Eastman ; Sumana Chakravarty ; Eric R James ; Kenneth Udenze ; Suzanne Li ; Daniel E Sturdevant ; Robert W Gwadz ; Stephen F Porcella ; Ca role A L...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: SNP genotyping by SNP array Plasmodium falciparum Source Type: research
Abstract Malaria is prevalent in tropical and subtropical regions of the globe. With over 200 million cases reported annually, particularly in sub-Saharan Africa, it is an unnecessary burden to already overworked and ailing healthcare structures. Traditional medicine (TM) remains vibrant in most of these regions wherein plants often serve as the first line of defense against malaria. Given this fact as well as the successes elsewhere of therapies such as Artemisia annua emanating from evidence-based TM, interest in plants as a source of new antimalarial drugs has been rejuvenated. The bulbous plant family Amarylli...
Source: Fitoterapia - Category: Biochemistry Authors: Tags: Fitoterapia Source Type: research
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Source: Parasites and Vectors - Category: Microbiology Authors: Tags: Short report Source Type: research
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