Prognostic value of dual time point 18F-FDG PET/CT for invasive ductal breast cancer with axillary lymph node metastasis: Comparison with diffusion-weighted imaging and dynamic contrast-enhanced MRI

Conclusion: We found that only ADCavg and the percentage change of SUVmax during interval image acquisition time showed independent prognostic value along with pT diameter and ER status for RFS in IDC with metastatic ALN. Increasing SUVmax during the interval time would indicate the aggressiveness of cancer cells. ADC is a quantitative parameter that captures signal attenuation, which is providing further evidence of tumor aggressiveness. In this study, we found a correlation between %SUVmax and ADCavg using Pearson correlation analysis (r = -0.297; p = 0.0125).In conclusion, the current study demonstrates that percentage changes of SUVmax and ADCavg were inversely correlated and independently prognostic for RFS in patients who had IDC with metastatic ALN. Research Support: This research was supported by grants from the National Research Foundation (2015R1C1A1A02037051, 2012M3A9B6055379, 2015R1C1A2A01054113) of South Korea.
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Breast Cancer Source Type: research