Oligogalacturonic Acid Inhibits Vascular Calcification by Two Mechanisms: Inhibition of Vascular Smooth Muscle Cell Osteogenic Conversion and Interaction With Collagen.

CONCLUSIONS: Degree of polymerization of 8 inhibits vascular calcification development mainly by inhibition of osteogenic marker expression but also partly by masking the GFOGER sequence-thereby, preventing matrix vesicles from binding to COL1.
PMID: 28522698 [PubMed - as supplied by publisher]

Source: Arteriosclerosis, Thrombosis and Vascular Biology - May 18, 2017 Category: Cardiology Authors: Hodroge A, Trécherel E, Cornu M, Darwiche W, Mansour A, Ait-Mohand K, Verissimo T, Gomila C, Schembri C, Da Nascimento S, Elboutachfaiti R, Boullier A, Lorne E, Courtois J, Petit E, Toumieux S, Kovensky J, Sonnet P, Massy ZA, Kamel S, Rossi C, Ausseil J Tags: Arterioscler Thromb Vasc Biol Source Type: research