Detrimental Effects of Centrally Administered Angiotensin II are Enhanced in a Mouse Model of Alzheimer Disease Independently of Blood Pressure [Hypertension]

ConclusionsBrain angiotensin II seems to be involved in cognitive impairment and brain injury in AD, which is associated with oxidative stress, inflammation, and cerebral amyloid angiopathy. Further, brain angiotensin II may participate in cardiac disease and sarcopenia observed in AD.

Source: JAHA:Journal of the American Heart Association - April 20, 2017 Category: Cardiology Authors: Takane, K., Hasegawa, Y., Lin, B., Koibuchi, N., Cao, C., Yokoo, T., Kim-Mitsuyama, S. Tags: ACE/Angiotensin Receptors/Renin Angiotensin System, Basic Science Research, Cognitive Impairment Original Research Source Type: research