Insulin resistance promotes Lysyl Oxidase Like 2 induction and fibrosis accumulation in nonalcoholic fatty liver disease

Conclusions: IR favors fibrosis deposition independently of the classic "inflammation - HSC trans-differentiation" pathway. The mechanism entails a cross-talk between enhanced lipotoxicity in insulin resistant hepatocytes and Loxl2 production by HSCs, which was confirmed in patients with diabetes, thereby facilitating extracellular matrix stabilization.

Source: Clinical Science - May 3, 2017 Category: Biomedical Science Authors: Dongiovanni, P., Meroni, M., Baselli, G. A., Bassani, G. A., Rametta, R., Pietrelli, A., Maggioni, M., Facciotti, F., Trunzo, V., Badiali, S., Fargion, S., Gatti, S., Valenti, L. V. C. Tags: PublishAheadOfPrint Source Type: research