CSF biomarkers suggest a strong role of glial inflammation in the pathogenesis of frontotemporal dementia (P6.104)

Conclusions:FTD features increased YKL-40, sTREM2 and NfL, a profile that distinguishes it from controls and AD. The dynamic relationship between CSF neuroinflammatory and injury biomarkers and disease severity support a strong role for neuroinflammation in the progression of FTD.Study Supported by:NIH 2T32 AG023481, National Institutes of Health, 4-Repeat Tauopathy Neuroimaging Initiative (4RTNI, AG03879); the National Center for Advancing Translational Science (NCATS) and National Institute of Neurological Disorders and Stroke (NINDS), Advancing Research and Treatment for Frontotemporal Lobar Degeneration (ARTFL, NS092089); the National Institute of Aging, Frontotemporal Dementia: Genes, Images and Emotions (AG019724); the National Research Service Award, Institutional Research Training Grant (AG23481-11); the Tau Consortium and the Hillblom Foundation, Hillblom Aging Network (P0502788)Disclosure: Dr. Rojas -Martinez has nothing to disclose. Dr. Suarez Calvet has nothing to disclose. Dr. Karydas has nothing to disclose. Dr. Kleinberger has nothing to disclose. Dr. Kramer has nothing to disclose. Dr. Rosen has nothing to disclose. Dr. Rabinovici has received personal compensation for activities with Eisai, Roche, Lundbeck, and Putnam as a speaker or consultant. Dr. Rabinovici has received research support from NIH, Alzheimer's Association, Tau Consortium, American College of Radiology, Michael J Fox Foundation, Association for Frontotemporal Degneration, Avid Radiopharmaceut...

Source: Neurology - April 17, 2017 Category: Neurology Authors: -Martinez, J. R., Calvet, M. S., Karydas, A., Kleinberger, G., Kramer, J., Rosen, H., Rabinovici, G., Miller, B., Fagan, A., Haass, C., Boxer, A. Tags: Aging and Dementia Poster Discussion Session: Novel Approaches in Neurodegenerative Diseases: Genetics, Biomarkers, and Therapies Source Type: research