What does the humanized monoclonal anti-CGRP antibody (TEV-48125) teach us about the perception of migraine headache? (P2.159)

Conclusions:For patients whose chronic and episodic migraines are relieved by the CGRP-mAb, the findings raise the possibility that HT neurons play a critical role (not recognized before) in the initiation and chronification of the perception of headache whereas WDR neurons contribute to the associated allodynia and central sensitization. Clinically, the findings may help explain why the therapeutic effects of CGRP-mAb are selective to headaches of intracranial origin such as migraine and why this therapeutic approach may not be effective for every migraine patient.Study Supported by:Teva PharmaceuticalsNIH Grants: R37 NS079678 and NS085510Disclosure: Dr. Melo-Carrillo has nothing to disclose. Dr. Strassman has nothing to disclose. Dr. Schain has nothing to disclose. Dr. Reuven-Nir has nothing to disclose. Dr. Burstein has received personal compensation for activities with Allergan, GSK, and Merck as a consultant or member of the scientific advisory board.
Source: Neurology - Category: Neurology Authors: Tags: Headache: Basic and Clinical Science Source Type: research