The isoprenoid derivative N6 ‐benzyladenosine (CM223) exerts antitumor effect in glioma patient‐derived primary cells through the mevalonate pathway.

Conclusion and ImplicationsThis biological effect together with structural data on interaction of CM223 with FPPS, gain additional evidence on the correlation of the i6A/CM223 antitumoral activity with FPPS modulation. Because the MVA pathway is becoming an important promising target, CM223 and derivatives should be considered interesting active molecules in antiglioma pharmacological research.
Source: British Journal of Pharmacology - Category: Drugs & Pharmacology Authors: Tags: RESEARCH PAPER Source Type: research