Request for Letters of Intent: Diabetic Retinopathy Biomarker Discovery and Validation

Request for Letters of Intent: Diabetic Retinopathy Biomarker Discovery and Validation LOI Submission Deadline: .June 20th 2014 JDRF is committed to facilitating the translation of pre-clinical discovery of promising targets or therapeutics in diabetic retinopathy to the patient with Type 1 Diabetes (T1D). To this end, JDRF is soliciting letters of intent for research to identify and validate predictive and prognostic biomarkers for diabetic retinopathy (DR). Diabetic retinopathy is a sight-threatening complication of diabetes and the largest cause of blindness in the US. Despite recent advances in the treatment of diabetic macular edema, there remains a large unmet clinical need to prevent or reverse vision loss via the treatment of earlier stages of disease, such as non-proliferative diabetic retinopathy (NPDR). Progression of NPDR to vision-threatening consequences can be slow creating a challenge in the design of clinical trials to treat disease at the earliest possible stage. The refore novel biomarkers are needed to identify NPDR patients that are at highest risk for progression to more severe disease. In addition, to increase information that can be gained from clinical trials, shorter-term biomarkers are needed which may predict treatment response as surrogates to endpoints currently accepted by regulators, such as differences in visual acuity or 3-step progression on the Early Treatment Diabetic Retinopathy Study (ETDRS) scale. OBJECTIVES Letters of inten...
Source: ScanGrants feed - Category: Research Authors: Source Type: funding

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Authors: Sun PO, Schyns MVP, Walbeehm ET Abstract Carpal tunnel syndrome (CTS) is the most frequently operated neurological disorder of the hand. Incidence of patients remaining symptomatic has been reported up to 30% after primary release. Revision surgery remains challenging although multiple surgical options have been described. In this case series a simple novel technique, the palmaris longus interposition, is described for the treatment of recurrent and persistent CTS. Patients who underwent PLI between October 2013 and 2018 and without underlying neurological or hand disorders severely affecting the operated ...
Source: Journal of Plastic Surgery and Hand Surgery - Category: Surgery Tags: J Plast Surg Hand Surg Source Type: research
Conclusion: It was demonstrated that λ/2- and λ/4-pitch configurations result in better LR and contrast than λ-pitch configuration. Significance: Based on the results obtained, the proposed method has the potential to serve as an easy-to-integrate and simple way of achieving better image quality without requiring to increase the system complexity with existing transducer array probe technology in regular clinical- scanners.
Source: IEEE Transactions on Biomedical Engineering - Category: Biomedical Engineering Source Type: research
Nonintubated thoracic surgery arose as supplemental evolution of minimally invasive surgery and is gaining popularity. A proper nonintubated thoracic surgery unit is mandatory and should involve surgeons, anesthesiologists, intensive care physicians, physiotherapists, psychologists, and scrub and ward nurses. Surgical training should involve experienced and young surgeons. It deserves a step-by-step approach and consolidated experience on video-assisted thoracic surgery. Due to difficulty in reproducing lung and diaphragm movements, training with simulation systems may be of scant value; instead, preceptorships and invited...
Source: Thoracic Surgery Clinics - Category: Cardiovascular & Thoracic Surgery Authors: Source Type: research
Conclusions School-going indigenous adolescents in rural Panama have substantial STI burden. Targeted STI screening is required.
Source: Sexually Transmitted Diseases - Category: Sexual Medicine Tags: Original Studies Source Type: research
Conclusion: No tumor-related frequencies were found, neither using systematic scans of frequencies nor published specific frequencies. There might obviously be differences between animal and human models, but our approach did not confirm the physiological data of the human Pasche group data. PMID: 31746658 [PubMed - as supplied by publisher]
Source: International Journal of Radiation Biology - Category: Radiology Tags: Int J Radiat Biol Source Type: research
CONCLUSIONS: Our AATR shows the capabilities of adapting to varying types of materials, even the unknown materials which are not available in the training data, adapting to varying required probability of detection and adapting to varying scales of the threat object. PMID: 31744038 [PubMed - as supplied by publisher]
Source: Journal of X-Ray Science and Technology - Category: Radiology Tags: J Xray Sci Technol Source Type: research
Authors: Cheng Y, Bai L, Shang J, Tang Y, Ling X, Guo B, Gong J, Wang L, Xu H Abstract The present study aimed to assess the performance of positron emission tomography‑magnetic resonance imaging (PET/MR) for the visualization and characterization of lesions. In addition, the present study investigated whether the apparent diffusion coefficient (ADC) and intravoxel incoherent motion parameters exhibited any significant correlation with standardized uptake values (SUV) in patients with nasopharyngeal carcinoma (NPC). A total of 35 patients with NPC underwent whole body PET‑computed tomography (CT) and head ...
Source: Oncology Reports - Category: Cancer & Oncology Tags: Oncol Rep Source Type: research
CONCLUSIONS: This study indicates a relationship between antipsychotic adherence and improved diabetes outcomes among individuals with schizophrenia. Engagement in mental health treatment may be a critical path toward improving health disparities for individuals with schizophrenia. Individuals with very low to no engagement were a particularly vulnerable group, and the exclusion of persons with less than two prescriptions from research and quality measures should be revisited. PMID: 31744428 [PubMed - as supplied by publisher]
Source: Psychiatric Services - Category: Psychiatry Tags: Psychiatr Serv Source Type: research
Sarah K. Azzam1, Wael M. Osman2, Sungmun Lee1, Kinda Khalaf1, Ahsan H. Khandoker1, Wael Almahmeed3,4, Herbert F. Jelinek5 and Habiba S. Al Safar1,2* 1Biomedical Engineering Department, Khalifa University of Science and Technology, Abu Dhabi, United Arab Emirates 2Khalifa University Center of Biotechnology, Abu Dhabi, United Arab Emirates 3Institute of Cardiac Science, Sheikh Khalifa Medical City, Abu Dhabi, United Arab Emirates 4Heart and Vascular Institute, Cleveland Clinic, Abu Dhabi, United Arab Emirates 5Australian School of Advanced Medicine, Sydney and School of Community Health, Charles Sturt University, Ma...
Source: Frontiers in Endocrinology - Category: Endocrinology Source Type: research
This study defines a new clinically relevant concept of T-cell senescence-mediated inflammatory responses in the pathophysiology of abnormal glucose homeostasis. We also found that T-cell senescence is associated with systemic inflammation and alters hepatic glucose homeostasis. The rational modulation of T-cell senescence would be a promising avenue for the treatment or prevention of diabetes. Intron Retention via Alternative Splicing as a Signature of Aging In recent years researchers have inv...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
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