Dietary and pharmacological treatment of abdominal pain in IBS

The objectives of this review are to appraise the physiology and anatomy of gut sensation and the efficacy in the relief of visceral pain (typically in IBS) of several classes of therapies. These include fermentable oligosaccharides, disaccharides, monosaccharides and polyols (FODMAPs) and different classes of medications (box 1). Box 1 Classes of pharmacological agents for visceral painAntidepressants (tricyclic agents, selective serotonin reuptake inhibitors) Peppermint oil 5-HT3 receptor antagonists (alosetron, ondansetron, ramosetron) Non-absorbed antibiotic (rifaximin) Secretagogues (lubiprostone, linaclotide) μ-Opioid receptor (OR) and -OR agonist and -OR antagonist (eluxadoline) Histamine H1 receptor antagonist (ebastine) Neurokinin-2 receptor antagonist (ibodutant) GABAergic agents (gabapentin and pregabalin)
Source: Gut - Category: Gastroenterology Authors: Tags: GUT Recent advances in clinical practice Source Type: research