PM2.5-induced alterations of cell cycle associated gene expression in lung cancer cells and rat lung tissues

In conclusion, PM2.5 can induce significantly alterations of p53 and CDK2 in the early phase, Cdc2 and cyclin B in mid-term and p21 in long-term exposure. The degree of PM2.5-induced damage to the trachea and lung tissue was time-dependent.
Source: Environmental Toxicology and Pharmacology - Category: Environmental Health Source Type: research

Related Links:

Precise medical imaging and analysis could enable early detection of lung cancer, help determine its exact size and location, and significantly improve diagnosis and treatment. This is usually done in a process called segmentation, which uses computers to identify the boundaries of the lung from surrounding thoracic tissue on CT images. From this process, a detailed 3-D map of the airways may be generated that can help to plan and navigate a bronchoscopy procedure to obtain biopsy samples and to perform other clinical interventions. “Until now, t...
Source: MDDI - Category: Medical Devices Authors: Tags: Imaging Source Type: news
We report an unusual case of a patient with persistent cough and dyspnoea in the context of prior chemoradiotherapy for primary lung cancer who was subsequently found to have invasive tracheobronchial aspergillosis of the distal trachea and proximal of right main bronchus. Invasive tracheobronchial aspergillosis is a rare disease with most reported cases in the literature occurring in immunocompromised hosts. We report an unusual case of a patient with persistent cough and dyspnoea in the context of prior chemoradiotherapy for primary lung cancer. Chest computed tomography (CT) demonstrated an abnormal soft tissue mass sur...
Source: Respirology Case Reports - Category: Respiratory Medicine Authors: Tags: Case Report Source Type: research
Mark E. Gray1,2*, James Meehan2,3, Paul Sullivan4, Jamie R. K. Marland4, Stephen N. Greenhalgh1, Rachael Gregson1, Richard Eddie Clutton1, Carol Ward2, Chris Cousens5, David J. Griffiths5, Alan Murray4 and David Argyle1 1The Royal (Dick) School of Veterinary Studies and Roslin Institute, University of Edinburgh, Edinburgh, United Kingdom 2Cancer Research UK Edinburgh Centre and Division of Pathology Laboratories, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, United Kingdom 3School of Engineering and Physical Sciences, Institute of Sensors, Signals and Systems, Heriot-Watt Univer...
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
Conclusions: As compared to 3DCT, 4DCT scans deliver more organ doses, especially for pediatric patients. Substantial increase in lung cancer risk is associated with higher radiation dose from 4DCT and smaller patients' size as well as younger age. PMID: 30345309 [PubMed - in process]
Source: Biomed Res - Category: Research Authors: Tags: Biomed Res Int Source Type: research
Conclusion: An iterative thresholding method for automatic lung segmentation has been described, capable of producing lung VOIs with DSCs comparable to the results of atlas segmentation with multiple best matches. This permits individuals without access to atlas segmentation methods to accurately and automatically generate lung VOIs. Reference: Pirozzi S, Horvot M, Piper J, Nelson AS. Atlas-based Segmentation: Evaluation of a Multi-Atlas Approach for Lung Cancer. Med Phys 2012; 39:3677.
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Data Analysis & amp; Management Posters Source Type: research
CONCLUSIONS: This work shows that there is benefit in using motion compensated reconstructions for reducing both inter-observer and intra-observer contouring variations for organs at risk in lung cancer patients. PMID: 29221648 [PubMed - as supplied by publisher]
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - Category: Radiology Authors: Tags: Radiother Oncol Source Type: research
Conclusions: Peroral arsenic has little effect on local airway immune responses to bacteria but compromises respiratory epithelial barrier integrity, increasing systemic translocation of inhaled pathogens and small molecules. https://doi.org/10.1289/EHP1878 Received: 09 March 2017 Revised: 14 August 2017 Accepted: 16 August 2017 Published: 28 September 2017 Address correspondence to M.B. Fessler, National Institute of Environmental Health Sciences, 111 T.W. Alexander Dr., P.O. Box 12233, Maildrop D2-01, Research Triangle Park, NC 27709 USA. Telephone: (919) 541-3701. Email: fesslerm@niehs.nih.gov *Current address: UN...
Source: EHP Research - Category: Environmental Health Authors: Tags: Research Source Type: research
CONCLUSIONS: Anatomical changes during radiotherapy caused one or more OAR constraint violations for approximately half of the patient cohort. The main cause was tumour shrinkage. For lung cancer radiotherapy dose escalation trials, we recommend incorporation of adaptive radiotherapy strategies. PMID: 28830293 [PubMed - as supplied by publisher]
Source: Acta Oncologica - Category: Cancer & Oncology Authors: Tags: Acta Oncol Source Type: research
Over the last half century, technology has made possible the probing of the solar system and galaxy beyond. People can instantly correspond with anyone in the world. We can see —in real time—events and phenomena heretofore only reported by second and third hand accounts. Yet with all of the distance breached by modern devices, we are also able to know in detail the goings on inside our own bodies. With the advent of computed tomography (CT) imaging, known familiarly as “CAT scans,” doctors and their patients now get a bird’s eye view of internal organs. This scientific know-how goes beyond sim...
Source: ePharma Summit - Category: Pharmaceuticals Tags: Anatomy CT Scan Lungs Medical Devices Source Type: blogs
ConclusionsModerate prescription dosing, treated once weekly, offers acceptable local control rates for centrally located tumors including recurrent mediastinal and hilar lymph nodes. Toxicity was minimal with the majority of patients experiencing no treatment-related adverse events.
Source: Journal of Radiation Oncology - Category: Cancer & Oncology Source Type: research
More News: Cancer | Cancer & Oncology | Drugs & Pharmacology | Environmental Health | Genetics | Lung Cancer | PET Scan | Study | Toxicology | Tracheal Cancer