Subchronic toxicity studies of aqueous leaf and stem bark extract of Irvingia gabonensis in male albino wistar rats

This study investigated the effect of aqueous leaf and stem bark extracts ofI. gabonensis on the haematology, pathomorphology and some clinical chemistry profiles of male albino wistar rats following subchronic exposure. The extract was administered using the oral route. Group A served as control and was given only distilled water. Groups B, C and D were treated with the extract at 100, 1000 and 2000  mg/kg, respectively. The parameters assessed to determine the effect of subchronic administration of the extract were: packed cell volume (PCV), haemoglobin concentration (Hb), total red blood cell count (TRBC), total white blood cell count (TWBC), differential white blood cell count (DWBC), alani ne aminotransferase (ALT), aspartate aminotransferase (AST) and alkaline phosphatase (ALP) and histopathology of the heart, liver, spleen, kidney and testes. The data obtained were subjected to one-way analysis of variance (ANOVA). Values were considered statistically significant atp <  0.05. The haematological values obtained from the treatment groups did not show any significant difference from the control. Likewise, the serum biochemistry values obtained from the treatment groups did not differ significantly from the control. Histopathological evaluation of the testes showed t esticular degeneration in groups C (1000 mg/kg) and D (2000 mg/kg). The findings of this study suggest thatI. gabonensis may have a reprotoxic effect following subchronic or long-term exposures.
Source: Comparative Clinical Pathology - Category: Pathology Source Type: research