Cancer Susceptibility Gene Mutations in Individuals With Colorectal Cancer.

Conclusion Germline cancer susceptibility gene mutations are carried by 9.9% of patients with CRC. MSI/MMR testing reliably identifies LS probands, although 7.0% of patients with CRC carry non-LS mutations, including 1.0% with BRCA1/2 mutations.
PMID: 28135145 [PubMed - as supplied by publisher]

Source: Clinical Colorectal Cancer - January 29, 2017 Category: Cancer & Oncology Authors: Yurgelun MB, Kulke MH, Fuchs CS, Allen BA, Uno H, Hornick JL, Ukaegbu CI, Brais LK, McNamara PG, Mayer RJ, Schrag D, Meyerhardt JA, Ng K, Kidd J, Singh N, Hartman AR, Wenstrup RJ, Syngal S Tags: J Clin Oncol Source Type: research