DNA ploidy and cell cycle protein expression in oral squamous cell carcinomas with and without lymph node metastases

ConclusionThe results suggest that although there was dysregulation of cell cycle regulatory proteins, only Ki‐67 and the MCM2/Ki‐67 and geminin/Ki‐67 ratios may have prognostic significance in oral cancer. DNA ploidy alone was not specific and may not be a good tool to evaluate prognosis or metastatic progression in oral cavity carcinomas.This article is protected by copyright. All rights reserved.

Source: Journal of Oral Pathology and Medicine - January 30, 2017 Category: Pathology Authors: Ibtisam M Zargoun, L Bingle, P M Speight Tags: Original Article Source Type: research