Sickle Cell Trait and Renal Function in Hispanics in the United States: The Northern Manhattan Study.

Sickle Cell Trait and Renal Function in Hispanics in the United States: The Northern Manhattan Study. Ethn Dis. 2017 Jan 19;27(1):11-14 Authors: Dueker ND, Della-Morte D, Rundek T, Sacco RL, Blanton SH Abstract Sickle cell anemia (SCA) is a common hematological disorder among individuals of African descent in the United States; the disorder results in the production of abnormal hemoglobin. It is caused by homozygosity for a genetic mutation in HBB; rs334. While the presence of a single mutation (sickle cell trait, SCT) has long been considered a benign trait, recent research suggests that SCT is associated with renal dysfunction, including a decrease in estimated glomerular filtration rate (eGFR) and increased risk of chronic kidney disease (CKD) in African Americans. It is currently unknown whether similar associations are observed in Hispanics. Therefore, our study aimed to determine if SCT is associated with mean eGFR and CKD in a sample of 340 Dominican Hispanics from the Northern Manhattan Study. Using regression analyses, we tested rs334 for association with eGFR and CKD, adjusting for age and sex. eGFR was estimated using the Chronic Kidney Disease Epidemiology Collaboration equation and CKD was defined as eGFR < 60 mL/min/1.73 m(2). Within our sample, there were 16 individuals with SCT (SCT carriers). We found that SCT carriers had a mean eGFR that was 12.12 mL/min/1.73m(2) lower than non-carriers (P=.002). Additionally, S...
Source: Ethnicity and Disease - Category: Global & Universal Tags: Ethn Dis Source Type: research