Intraoperative Near-Infrared Optical Imaging Can Localize Gadolinium-Enhancing Gliomas During Surgery

CONCLUSION: With the use of Second Window ICG, gadolinium-enhancing tumors can be localized through brain parenchyma intraoperatively. Its utility for margin detection is promising but limited by lower specificity. ABBREVIATIONS: 5-ALA, 5-aminolevulinic acid EPR, enhanced permeability and retention FDA, Food and Drug Administration GBM, glioblastoma ICG, indocyanine green NIR, near-infrared NPV, negative predictive value PPV, positive predictive value ROC, receiver operating characteristic ROI, region of interest SBR, signal-to-background ratio WHO, World Health Organization
Source: Neurosurgery - Category: Neurosurgery Tags: Research-Human-Clinical Studies: Editor's Choice Source Type: research