Intraoperative Near-Infrared Optical Imaging Can Localize Gadolinium-Enhancing Gliomas During Surgery
CONCLUSION: With the use of Second Window ICG, gadolinium-enhancing tumors can be localized through brain parenchyma intraoperatively. Its utility for margin detection is promising but limited by lower specificity.
ABBREVIATIONS: 5-ALA, 5-aminolevulinic acid
EPR, enhanced permeability and retention
FDA, Food and Drug Administration
GBM, glioblastoma
ICG, indocyanine green
NIR, near-infrared
NPV, negative predictive value
PPV, positive predictive value
ROC, receiver operating characteristic
ROI, region of interest
SBR, signal-to-background ratio
WHO, World Health Organization
Source: Neurosurgery - Category: Neurosurgery Tags: Research-Human-Clinical Studies: Editor's Choice Source Type: research
More News: Astrocytoma | Brain | Brain Cancers | Brain Tumor | Glioma | International Medicine & Public Health | MRI Scan | Neurology | Neurosurgery | Pathology | Pilocytic Astrocytoma | Study | WHO