Exposure to type 2 diabetes and risk of coronary heart disease in Chinese men and women: findings from a cross-sectional national survey

Publication date: November 2016 Source:The Lancet Diabetes & Endocrinology, Volume 4, Supplement 1 Author(s): Xilin Yang, Yingying Luo, Xiaohui Guo, Xiaoxu Huo, Juming Lu, Yanfeng Ren, Linong Ji Background Coronary heart disease generally occurs more frequently in men than in women. Findings from small studies (n<5000) in white populations suggest that type 2 diabetes imparts a higher risk of coronary heart disease to women than to men. We aimed to investigate this association in Chinese women versus men. Methods We did a cross-sectional national survey in 223 612 Chinese patients (age ≥18 years; 120 252 men and 103 360 women) with type 2 diabetes in 630 hospitals from 106 cities in 30 provinces of China in 2012. Demographic information, medical history, and drug use were documented. Coronary heart disease was defined as ischaemic heart disease with abnormal electrocardiogram (ECG) or stress test, myocardial infarction with typical changes in ECG and plasma enzyme testing, coronary revascularisation, percutaneous transluminal coronary angioplasty, or coronary atherectomy. We used multivariable binary logistic regression analysis to obtain odds ratios (ORs) for coronary heart disease in women versus men, controlling for age, hospital level, BMI, glucose monitoring at home, diabetes medications, diabetic nephropathy, HbA1c, systolic blood pressure, diastolic blood pressure, LDL cholesterol, HDL cholesterol, and triglyceride. We used additive int...
Source: The Lancet Diabetes and Endocrinology - Category: Endocrinology Source Type: research