RNase A in (Xeno)Transplantation

ConclusionsRNase A significantly improved graft survival. On the basis of these sweeping results, however, we suppose that RNase A could be an important adjuvant drug not only in allotransplantation but even in xenotransplantation. References[1] Fischer S, Gerriets T, Wessels C, et al. Extracellular RNA mediates endothelial‐cell permeability via vascular endothelial growth factor. Blood 2007; 110(7): 2457–2465.[2] Kannemeier C, Shibamiya A, Nakazawa F, et al. Extracellular RNA constitutes a natural procoagulant cofactor in blood coagulation. Proc Natl Acad Sci U S A 2007; 104(15): 6388–6393.[3] Fischer S, Grantzow T, Pagel JI, et al. Extracellular RNA promotes leukocyte recruitment in the vascular system by mobilising proinflammatory cytokines. Thromb Haemost. 2012; 108(4): 730–741.[4] Walberer M, Tschernatsch M, Fischer S, et al. RNase therapy assessed by magnetic resonance imaging reduces cerebral edema and infarction size in acute stroke. Curr Neurovasc Res. 2009; 6(1): 12–19.
Source: Xenotransplantation - Category: Transplant Surgery Authors: Tags: Program and Abstracts Source Type: research