Sex-related factors influence expression of mood-related genes in the basolateral amygdala differentially depending on age and stress exposure

ConclusionsSex chromosome complement is an important factor modulating expression of mood-related genes during pre-pubertal development. The observed sex differences under chronically stressed conditions suggest that different molecular profiles may characterize male and female MDD. Our findings here forSst are especially interesting, and suggest an underlying XY vulnerability that is typically compensated for by circulating testosterone in “normal” males. Without testosterone, women may have lowerSST expression in the amygdala, resulting in increased MDD vulnerability.
Source: Biology of Sex Differences - Category: Biology Source Type: research