Successful Evaluation for Reversibility of Pulmonary Hypertension Using Inhaled Nitric Oxide Determining Candidate for Heart Transplantation

A 43-year old man, who admitted heart failure (HF) with severe left ventricular (LV) dysfunction and pulmonary hypertension (PH) due to Becker muscular dystrophy. Echocardiography revealed that LV ejection fraction was 21%, pulmonary systolic artery pressure (PASP) was 81  mmHg. Decompensated HF with PH was persistent in spite of optimal HF treatment including vasodilator, inotropes, angiotensin-converting enzyme inhibitors, beta-blockers and cardiac resynchronization therapy. We assessed the reversibility for pulmonary vascular resistance (PVR) using inhaled 20  ppm nitric oxide (NO), determining candidate for heart transplantation in the future.
Source: Journal of Cardiac Failure - Category: Cardiology Authors: Source Type: research

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In this study, olfactory ensheathing cells (OECs) were cultured, chitosan (CS) was prepared, and the compatibility of CS and OECs was detected by MTT method. Animal model of chronic constrictive sciatic nerve injury (CCI) was made, OECs and OECs+CS were transplanted to the region surrounding the chronic sciatic nerve injury, and the difference between the two groups in the treatment of NPP was compared. The mechanical withdrawal threshold (MWT) and thermal withdrawal latency (TWL) were measured by using behavioral method. In situ hybridization and Western-blotting were used to detect the expression of P2X4R mRNA and protei...
Source: Neuroscience Letters - Category: Neuroscience Source Type: research
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Source: The Annals of Thoracic Surgery - Category: Cardiovascular & Thoracic Surgery Source Type: research
Authors: De Vecchis R, Paccone A, Di Maio M Abstract INTRODUCTION: The guidelines of the Scientific Societies of Cardiology suggest limiting water intake in the diet as one of the non-pharmacological measures for the management of chronic heart failure. However, many patients with heart failure may suffer from severe thirst, even irrespective of a possible restricted fluid intake, and this has received relatively little attention in clinical studies. Moreover, definitive and irrefutable evidence that documents the efficacy of the limitation in water consumption on major cardiovascular outcomes is lacking. Therefore...
Source: Minerva Cardioangiologica - Category: Cardiology Tags: Minerva Cardioangiol Source Type: research
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Source: Annals of Medicine - Category: Internal Medicine Tags: Ann Med Source Type: research
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Source: Thyroid : official journal of the American Thyroid Association - Category: Endocrinology Tags: Thyroid Source Type: research
The role of PPAR gamma agonists - rosiglitazone and 15-deoxy-Δ12,14-prostaglandin J2 in experimental cyclosporine A hepatotoxicity. J Physiol Pharmacol. 2019 Dec;70(6): Authors: Sikora-Wiorkowska A, Smolen A, Czechowska G, Wiorkowski K, Korolczuk A Abstract Cyclosporine A (CsA) is an immunosuppressive drug used in transplantation and treatment of autoimmune diseases. Experimental studies revealed impairments in liver function and morphology among cyclosporine-treated animals. The aim of the study was to evaluate hepatoprotective activity of peroxisome-proliferator-activated receptors γ (PPA...
Source: Journal of Physiology and Pharmacology - Category: Drugs & Pharmacology Tags: J Physiol Pharmacol Source Type: research
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Source: Disease Markers - Category: Laboratory Medicine Tags: Dis Markers Source Type: research
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Source: Journal of Science and Medicine in Sport - Category: Sports Medicine Source Type: research
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Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health - Category: OBGYN Source Type: research
More News: Beta-Blockers | Cardiac Resynchronization Therapy | Cardiology | Heart | Heart Failure | Heart Transplant | Hypertension | Muscular Dystrophy | Pulmonary Hypertension | Reflex Sympathetic Dystrophy | Transplants