MOGE(S) classification for cardiomyopathies

MOGE(S) classification for cardiomyopathies Conventionally cardiomyopathies have been classified into hypertrophic, restrictive and dilated varieties [1]. This classification is based on the phenotye rather than the genotype. With advances in genetic studies, several genes related to cardiomyopathies have been described. Hence in 2013, World Heart Federation proposed a classification including the genotype and phenotype of cardiomyopathies called as MOGE(S) classification [2]. This system of classification resembles the TNM classification for malignant neoplasms [3]. The reason for adding genotype information to the classification was the difference in risks asssociated with various genetic patterns. Arrhythmic risk was higher in troponinopathies even without severe left ventricular wall thickness [4]. In laminopathies arrhythmic risk may manifest even before severe left ventricular dysfunction [5]. But dystrophinopathies have lower arrhythmic risk inspite of gross left ventricular enlargement and dysfunction [6]. MOGE(S) nomenclature system has 5 atttributes: M: Morphofunctional characteristic O: Organ involvement G: Genetic or familial inheritence pattern E: Etiological annotation S: Functional status using stages A-D of American College of Cardiology/American Heart Association (ACC/AHA) staging, and classes I-IV using New York Heart Association (NYHA) functional classification. MD stands for dilated cardiomyopathy, MH for hypertrophic cardiomyopathy, MA for arr...
Source: Cardiophile MD - Category: Cardiology Authors: Tags: Cardiology Featured Source Type: blogs