Lipocalin-2 deficiency or blockade protects against aortic abdominal aneurysm development in mice

Conclusion
Either Lcn2 deficiency or anti-Lcn2 antibody blockade limits AAA expansion in mice by decreasing PMN infiltration in the aorta. Lcn2 modulation may therefore be a viable new therapeutic option for the treatment of AAA.

Source: Cardiovascular Research - July 21, 2016 Category: Cardiology Authors: Tarin, C., Fernandez-Garcia, C. E., Burillo, E., Pastor-Vargas, C., Llamas-Granda, P., Castejon, B., Ramos-Mozo, P., Torres-Fonseca, M. M., Berger, T., Mak, T. W., Egido, J., Blanco-Colio, L. M., Martin-Ventura, J. L. Tags: Vascular Biology Source Type: research