miR-223-IGF-IR signalling in hypoxia- and load-induced right-ventricular failure: a novel therapeutic approach

Conclusion
These findings highlight the early role of pulmonary and right-ventricular miR-223 and the IGF-IR in the right heart failure programme initiated by pulmonary hypoxia and increased mechanical load and may lead to the development of novel therapeutic strategies that target the development of PH and right heart failure.

Source: Cardiovascular Research - July 21, 2016 Category: Cardiology Authors: Shi, L., Kojonazarov, B., Elgheznawy, A., Popp, R., Dahal, B. K., Böhm, M., Pullamsetti, S. S., Ghofrani, H.-A., Gödecke, A., Jungmann, A., Katus, H. A., Müller, O. J., Schermuly, R. T., Fisslthaler, B., Seeger, W., Fleming, I. Tags: Integrative physiology and pathophysiology Source Type: research