Lots More Whining

Just can't get enough of it! Last Wednesday's visit to Mayo Clinic marked the end of the every-week 200-mile round trips, but the results didn't shed much light on my medical condition.  Is the "flare" in my vertebrae due to the myeloma itself, or is it inflammation caused by my immune system attacking the myeloma?  We're hoping for the latter, of course, and sticking with the current medication study, but this does require more than a little faith. Here is the whining:   Last night I was quite uncomfortable for much of the night.  The neuropathic pain on the right side of my back became much worse, perhaps 6 or 7 out of 10, and was accompanied by an abdominal ache that almost felt like it was kidney-related.  I was a little nauseous.   Unable to sleep, I took a naproxen (Aleve) liquid gel, sat at my computer for an hour, and then was able to sleep.  Today the naproxen has worn off, and the pain remains. So what could it be? Last Wednesday I had my very first infusion of zoledronic acid (Zometa), which is used to strengthen the bones of myeloma patients.  The prescribing doctor informed me that I might feel "achy" for a few days, especially because this was my first infusion. Indeed, a quick review of the literature suggests that it can cause all of the symptoms that I am experiencing.  If so, those symptoms should abate within a few days after the infusion. Also last Wednesday I started a prescr...
Source: Myeloma Hope - Category: Cancer & Oncology Source Type: blogs

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Publication date: Available online 17 January 2020Source: Radiation Physics and ChemistryAuthor(s): R. Rajaramakrishna, Y. Ruangtaweep, S. Sattayaporn, P. Kidkhunthod, S. Kothan, J. KaewkhaoAbstractCe3+: Dy3+- codoped calcium zinc gadolinium borate glasses were synthesized by traditional melt quenching technique. These glasses after synthesizing they were characterized through density, molar volume, refractive index, FTIR, absorption spectra, photoluminescence properties, structural studies using XANES/EXAFS and life time profile analysis. XANES spectra of Gd LIII-edge and Dy LIII-edge for 20CaCO3 - 20 ZnO - 10Gd2O3 - 49.5...
Source: Radiation Physics and Chemistry - Category: Physics Source Type: research
Publication date: Available online 18 January 2020Source: Life SciencesAuthor(s): Zhipei Liu, Yuzhong Jia, Lv Song, Youjia Tian, Peipei Zhang, Peihua Zhang, Zhenzhen Cao, Jihua MaAbstractAimsDetect the antiarrhythmic effect of crotonoside (Cro).Main methodsWe used whole-cell patch-clamp techniques to detect the effects of Cro on action potentials (APs) and transmembrane ion currents in isolated rabbit left ventricular myocytes. We also verified the effect of Cro on ventricular arrhythmias caused by aconitine in vivo.Key findingsCro reduced the maximum depolarization velocity (Vmax) of APs and shortened the action potential...
Source: Life Sciences - Category: Biology Source Type: research
This study demonstrated that CaO-stabiliser interaction largely determines the CO2 capture performance of CaO-based sorbents, and the Ca/Si ratio in the BFS-derived sorbent should be effectively controlled to allow the material to capture CO2 at a high performance.
Source: Chemical Engineering Journal - Category: Chemistry Source Type: research
Publication date: Available online 14 January 2020Source: Chemical Engineering JournalAuthor(s): Keke Wu, Xiaoxian Wu, Meng Chen, Haoming Wu, Yanpeng Jiao, Changren ZhouAbstractInflammation or infectious wound could produce high level of hydrogen peroxide (H2O2), which may prevent wound healing process. It could be directly monitored the generated H2O2 to determine the wound microenvironment, which related to its healing status. Europium(III) Coordination Polymers (Eu CPs) had the ability to detect the level of H2O2 and promote wound healing. Thus, a H2O2-responsive smart dressing, fabricated by loading Eu CPs into polyacr...
Source: Chemical Engineering Journal - Category: Chemistry Source Type: research
Publication date: 18 January 2020Source: New Scientist, Volume 245, Issue 3265Author(s): Alice Klein
Source: New Scientist - Category: Science Source Type: research
In this study, key factors of calcification and microbial behaviors especially methanogens of calcified anaerobic granule (AnGS) were investigated in batch assays with calcium level varying from 0 to 5 g L-1. The results showed that the COD removal efficiency and specific methane activity of calcified AnGS were restrained with calcium addition, especially high calcium (>2 g L-1), and little tolerance of calcified AnGS to Ca2+ was underlined compared with non-calcified AnGS. Analysis of calcium mass flow from solution to sludge validated the formation of calcium precipitates influenced by calcium concentrat...
Source: Journal of Hazardous Materials - Category: Environmental Health Source Type: research
Publication date: Available online 17 January 2020Source: Journal of Photochemistry and Photobiology B: BiologyAuthor(s): Sandy Winfield Jere, Nicolette Nadene Houreld, Heidi AbrahamseAbstractPhotobiomodulation therapy (PBMT) is a curative technique that uses low intensity light to relegate pain and inflammation, and accelerate tissue repair. At a molecular level, the effects of photobiomodulation (PBM) are not fully established. The present study aimed to assess the impact of PBM on the alteration of genes linked to Janus kinase-Signal transducer and activator of transcription (JAK-STAT) signalling in wounded and diabetic...
Source: Journal of Photochemistry and Photobiology B: Biology - Category: Speech-Language Pathology Source Type: research
This report describes the case of a 20 years old man who was diagnosed with a mass involving the small intestine and bladder during the course of investigations for faecaluria and abdominal pain. Histopathological examination of the biopsies during cystoscopy revealed: muscle invasive transitional cell carcinoma, while the computerized tomography scan had confirmed the enterovesical fistula.The patient was traited by Radical cystectomy with extended pelvic lymph node dissection and ileocecal resection as ultimate curative treatment.
Source: Urology Case Reports - Category: Urology & Nephrology Source Type: research
Publication date: Available online 17 January 2020Source: European UrologyAuthor(s): Kwang Jin Ko, Won Jin Cho, Young-Suk Lee, Joongwon Choi, Hye Jin Byun, Kyu-Sung LeeAbstractBackgroundInterstitial cystitis/bladder pain syndrome (IC/BPS) is a chronic condition characterized by chronic pelvic pain related to the bladder with no effective treatment options.ObjectiveTo evaluate the efficacy and safety of transurethral resection (TUR) and transurethral coagulation (TUC) as treatments for Hunner lesion (HL) in IC/BPS.Design, setting, and participantsA single-center, prospective, randomized controlled trial involving 126 patien...
Source: European Urology - Category: Urology & Nephrology Source Type: research
ConclusionsRARP with the da Vinci SP is feasible and safe. Therefore, the step-by-step technique described in this study could be considered an option to perform radical prostatectomies. However, we still need better-designed studies to compare the outcomes with those of the multiport platform.Patient summaryWe reported our step-by-step technique describing a safe approach to robotic-assisted radical prostatectomy during the transition from the Xi to the da Vinci single-port robot.
Source: European Urology - Category: Urology & Nephrology Source Type: research
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